2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glycosidase

Glycosidase

Glycosidase

Glycosidase

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Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N3542
    Carpachromene
    		Inhibitor 98.84%
    Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway.
    Carpachromene
  • HY-E70132
    Endo-β-N-acetylglucosaminidase D
    Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate.
    Endo-β-N-acetylglucosaminidase D
  • HY-E70882
    Endoglycosidase D (N322Q mutant)
    Endoglycosidase D (N322Q mutant) (EndoD N322Q) is a mutant endoglycosidase, which can be highly efficient to transfer Man5GlcNAc oxazoline to a similar cyclic glycopeptide carrying two free GlcNAc moieties to give a doubly glycosylated peptide.
    Endoglycosidase D (N322Q mutant)
  • HY-W112651
    2,4,6-Triphenylaniline
    		Inhibitor
    2,4,6-Triphenylaniline has anti-diabetic activity and can be encapsulated in nano-emulsions (NE) to enhance stability and permeability. The NE loaded with 2,4,6-Triphenylaniline inhibits α-glucosidase and α-amylase.
    2,4,6-Triphenylaniline
  • HY-138815
    (S)-N-(1H-Indole-3-acetyl)tryptophan
    		Inhibitor 99.87%
    (S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase.
    (S)-N-(1H-Indole-3-acetyl)tryptophan
  • HY-N8018
    Leucosceptoside A
    		Inhibitor
    Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM).
    Leucosceptoside A
  • HY-P2929C
    PNGase F (Lyophilized)
    PNGase F (Lyophilized), a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F (Lyophilized) removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F (Lyophilized) can release N-glycans from glycoproteins in glycoanalytical workflows.
    PNGase F (Lyophilized)
  • HY-P2929B
    PNGase F (Immobilized, Microspin)
    PNGase F (Immobilized, Microspin) is a resin in which PNGase F (peptide N-glycosidase F) is covalently coupled to agarose beads, and it is used to remove N-glycans from antibodies, fusion proteins and other N-glycosylated proteins. The enzyme is recombinantly expressed in Escherichia coli, with its sequence derived from Flavobacterium meningsepticum.
    PNGase F (Immobilized, Microspin)
  • HY-137812
    p-Nitrophenyl β-D-lactoside
    		Substrate
    p-Nitrophenyl β-D-lactoside is a substrate of β-lactosidase and can be used to determine β-lactosinase activity. p-Nitrophenyl β-D-lactoside is a substrate of cellobiohydrolase. p-Nitrophenyl β-D-lactoside is a class of biochemical reagents used in glycobiology research.
    p-Nitrophenyl β-D-lactoside
  • HY-N0464S
    Quinic acid-13C3
    		Inhibitor 99.5%
    Quinic acid-13C3 is the 13C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC50=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC50 =93.75 μg/mL). D-(-)-Quinic acid is orally active.
    Quinic acid-<sup>13</sup>C<sub>3</sub>
  • HY-E70879
    Endoglycosidase M (N175Q mutant)
    Endoglycosidase M (N175Q mutant) (EndoM N175Q) can transfer natural N-glycans or oxazoline N-glycans to any peptide or protein with a GlcNAc residue to form a β1-4-glycosidic linkage. Endoglycosidase M (N175Q mutant) is a useful tool in the synthesis of homogeneous glycopeptides and glycoproteins.
    Endoglycosidase M (N175Q mutant)
  • HY-N8517
    Malabaricone B
    		Inhibitor 99.93%
    Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.
    Malabaricone B
  • HY-N7763
    Casuarictin
    		Inhibitor 98.62%
    Casuarictin is a potent and competitive α-glucosidase inhibitor with an IC50 of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research.
    Casuarictin
  • HY-N2383
    Validamine
    		Inhibitor
    Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme.
    Validamine
  • HY-N13248
    Mulberry Leaf Extract
    		Inhibitor
    Mulberry Leaf Extract is a mulberry leaf extract, and its components include: 1-Deoxynojirimycin. Mulberry Leaf Extract can effectively alleviate the adverse effects of high-fat diet on blood lipids and renal function, regulate lipid metabolism abnormalities, and significantly inhibit the accumulation of glycosylated substances in glomeruli. Mulberry Leaf Extract can regulate the key signaling pathways of diabetic nephropathy, but does not directly affect blood glucose levels..
    Mulberry Leaf Extract
  • HY-N10413
    Diphlorethohydroxycarmalol
    		Inhibitor 98.46%
    Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities.
    Diphlorethohydroxycarmalol
  • HY-B1039AR
    Ambroxol hydrochloride (Standard)
    		Activator
    Ambroxol (hydrochloride) (Standard) is the analytical standard of Ambroxol (hydrochloride). This product is intended for research and analytical applications. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
    Ambroxol hydrochloride (Standard)
  • HY-W056439
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
    		Activator
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine can increase the activity of β-glucocerebrosidase by 20%. N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine can be used in the study of lysosomal storage diseases and other protein storage diseases.
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
  • HY-N3078
    p-Hydroxyphenethyl trans-ferulate
    		Inhibitor 99.68%
    p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast α-glucosidase, IC50=19.24 ± 1.73 µM), antioxidant, and anti-inflammatory activities. p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity.
    p-Hydroxyphenethyl trans-ferulate
  • HY-148925
    α-Amyrenone
    		Inhibitor 98.83%
    α-Amyrenone is a triterpenoid that occurs naturally in very low concentrations in several oleoresins from Brazilian Amazon species of Protium (Burseraceae). The mixture of α and β-amyrenone inhibits α-glucosidase, and can reduce mechanical hypersensitivity and paw-oedema induced by carrageenan.
    α-Amyrenone
Cat. No. Product Name / Synonyms Application Reactivity