Diphlorethohydroxycarmalol 

Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities^[1].

IC50: 0.16 mM (α-glucosidase) and 0.53 mM (α-amylase) ^[1]

The increase of postprandial blood glucose levels are significantly suppressed in the Diphlorethohydroxycarmalol-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) is significantly reduced via Diphlorethohydroxycarmalol (100 mg/kg; p.o.) administration (2022 versus 2210 mmol x min/lL) in the diabetic mice as well as it delays absorption of dietary carbohydrates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

512.38

C₂₄H₁₆O₁₃

138529-04-1

OC1=CC(O)=C(OC2=C(O)C(O)=C3OC4=CC(O)=C(OC5=CC(O)=CC(O)=C5)C(O)=C4OC3=C2)C(O)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Soo-Jin Heo, et al. Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol. 2009 Aug 1;615(1-3):252-6.  [Content Brief]