LXR Agonist

LXR Agonists (26):

Cat. No.	Product Name	Effect	Purity

HY-10626

T0901317	Agonist	99.89%
T0901317 is an orally active and highly selective LXR agonist with an EC₅₀ of 20 nM for LXRα. T0901317 activates FXR with an EC₅₀ of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

HY-10627A

GW3965 hydrochloride	Agonist	99.92%
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively.

HY-N2371

27-Hydroxycholesterol	Agonist	99.96%
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-10629

LXR-623	Agonist	99.48%
LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC₅₀s of 24 nM and 179 nM, respectively.

HY-129098

DMHCA	Agonist	99.80%
DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects and can be used for the research of cholesterol homeostasis diabetes.

HY-18282

AZ876	Agonist	99.93%
AZ876 is a potent and high-affinity LXR agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.

HY-111498A

RGX-104	Agonist	99.97%
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-101973

XL041	Agonist	99.19%
XL041 (BMS-852927) is an LXRβ-selective agonist.

HY-123402

GSK3987	Agonist	99.75%
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation.

HY-19919

BMS-779788	Agonist	99.86%
BMS-779788 is a LXR partial agonist with IC₅₀ values of 68 nM for LXRα and 14 nM for LXRβ.

HY-111498

RGX-104 hydrochloride	Agonist	99.88%
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-123148

IMB-808	Agonist	99.85%
IMB-808 is a potent LXRα/β dual agonist with EC₅₀ values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research.

HY-154928

GW6340	Agonist	99.64%
GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT).

HY-125772

Acetyl podocarpic acid anhydride	Agonist	≥99.0%
Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor(LXR) agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and research of atherosclerosis, especially in the context of low HDL levels.

HY-N3216

Nagilactone B	Agonist	≥98.0%
Nagilactone B is a liver X receptor (LXR) agonist.

HY-D1734

FITC-GW3965	Agonist	≥98.0%
FITC-GW3965 is a fluorescence-labelled liver X receptor β (LXRβ) agonist GW3965 (HY-10627). FITC-GW3965 is a tracer, that can be designed by replacing the trifluoromethyl of GW3965 with an amide to link the FITC. FITC-GW3965 can be used to study the function of LXRβ.

HY-10627

GW3965	Agonist
GW3965 is a potent, selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively.

HY-100469

LXRβ agonist-2	Agonist
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC₅₀ of 7 nM, displays 28.5-fold selectivity over LXRα (EC₅₀=200 nM) and used in the treatment of atherosclerosis.

HY-152262

LXRβ agonist-4	Agonist
LXRβ agonist-4 is a potent, orally active Liver X receptors (LXRs) agonist with an IC₅₀ value of 0.0078 μM for LXRβ. LXRβ agonist-4 inhibits RANKL-induced osteoclast differentiation and bone resorption. LXRβ agonist-4 can be used in research of osteoporosis.

HY-N2509

Iristectorigenin B	Agonist	99.49%
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β.

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