GW6340

Cat. No.: HY-154928: FAQs
Data Sheet SDS COA Handling Instructions

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GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT).

For research use only. We do not sell to patients.

GW6340 Chemical Structure

CAS No. : 405910-78-3

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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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Biological Activity
Purity & Documentation
References
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Description

GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT)^[1].

Molecular Weight

581.07

Formula

C₃₃H₃₂ClF₃N₂O₂

CAS No.

405910-78-3

Appearance

Oil

Color

Off-white to light yellow

SMILES

O=C(CC1=CC(OCCCN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC(C(F)(F)F)=C4Cl)=CC=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (172.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7210 mL	8.6048 mL	17.2096 mL
5 mM	0.3442 mL	1.7210 mL	3.4419 mL
10 mM	0.1721 mL	0.8605 mL	1.7210 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.30 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (4.30 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.64%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (248 KB) HNMR (120 KB) RP-HPLC (169 KB) LCMS (416 KB)

Handling Instructions (2659 KB)

References

[1]. Yasuda T, et al. Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):781-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7210 mL	8.6048 mL	17.2096 mL	43.0241 mL
	5 mM	0.3442 mL	1.7210 mL	3.4419 mL	8.6048 mL
	10 mM	0.1721 mL	0.8605 mL	1.7210 mL	4.3024 mL
	15 mM	0.1147 mL	0.5737 mL	1.1473 mL	2.8683 mL
	20 mM	0.0860 mL	0.4302 mL	0.8605 mL	2.1512 mL
	25 mM	0.0688 mL	0.3442 mL	0.6884 mL	1.7210 mL
	30 mM	0.0574 mL	0.2868 mL	0.5737 mL	1.4341 mL
	40 mM	0.0430 mL	0.2151 mL	0.4302 mL	1.0756 mL
	50 mM	0.0344 mL	0.1721 mL	0.3442 mL	0.8605 mL
	60 mM	0.0287 mL	0.1434 mL	0.2868 mL	0.7171 mL
	80 mM	0.0215 mL	0.1076 mL	0.2151 mL	0.5378 mL
	100 mM	0.0172 mL	0.0860 mL	0.1721 mL	0.4302 mL

GW6340 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW6340405910-78-3GW 6340GW-6340LXRLiver X receptorMacrophagecholesterol transportmRCTintestinalInhibitorinhibitorinhibit

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