LXRβ agonist-2
LXRβ agonist-2 is an orally active and selective LXRβ agonist. LXRβ agonist-2 increases high-density lipoprotein cholesterol levels without elevating plasma triglyceride levels. LXRβ agonist-2 decreases lipid accumulation area in the aortic arch. LXRβ agonist-2 can be used for the research of atherosclerosis.
For research use only. We do not sell to patients.
- CAS No.: 1949801-52-8
- Formula: C32H31F6N3O7
- Molecular Weight:683.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LXRβ |
LXRβ agonist-2 (Compound (-)-56) (0.01-10 μM; 24 h) potently and selectively activates LXRβ in GAL4-LXR luciferase assays using stably transfected CHO K-1 cells, with an EC50 of 0.007 μM and an LXRα/LXRβ selectivity ratio of 28.5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | AUC |
|---|---|---|---|---|
| Golden hamster[1] | 10 mg/kg | p.o. | 503 ng/mL | 3027 ng·h/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LDL receptor knock-out (male, 10 weeks old, fed western diet to induce atherosclerotic lesions)[1]
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Dosage:1 mg/kg; 3 mg/kg
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Administration:p.o.; daily; 10 weeks
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Result:Increased HDL-C to 115% of control levels.
Maintained LDL-C at 108% of control.
Increased plasma TG to 152% of control.
Reduced aortic arch lipid accumulation area to 62% of control (p < 0.05).
Increased HDL-C to 116% of control levels.
Maintained LDL-C at 97% of control.
Increased plasma TG to 166% of control.
Reduced aortic arch lipid accumulation area to 59% of control (p < 0.05).
Chemical Information
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CAS No. 1949801-52-8
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Molecular Weight 683.59
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Formula C32H31F6N3O7
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SMILES
OC(C(F)(F)F)(C(F)(F)F)C1=CC(CCC)=C(OC2=CC(O)=C(C(CN3C(N[C@@](C)(C4=NC=C(OC(C)C)C=C4)C3=O)=O)=O)C=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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