2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. IMB-808

IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research.

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IMB-808 Chemical Structure

IMB-808 Chemical Structure

CAS No. : 870768-70-0

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Based on 1 publication(s) in Google Scholar

IMB-808 Related Antibodies

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Description

IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research[1].

In Vitro

IMB-808 (0.001 μM-30 μM) significantly dose-dependently induces LXRβ activation under the concentrations ranged from 0.001 μM to 30 μM, with an EC50 of 0.53 μM. In a luciferase reporter assay IMB-808 using GAL4-pGL4-luc reporter plasmid, IMB-808 also could dose-dependently active LXRα with a lower EC50 of 0.15 μM[1].
IMB-808 (0 μM-10 μM; 18 hours) significantly increases protein and mRNA levels of ABCG1 as well as ABCA1 in RAW264.7 macrophages[1].
IMB-808 (0.1 μM, 0.3 μM, 1 μM, 3 μM, or 10 μM; 24 hours) promotes cholesterol efflux towards ApoA-I and HDL dose-dependently and reduces the cellular cholesterol concentration in these two cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMB-808 Related Antibodies
Molecular Weight

380.32

Formula

C18H15F3N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(CC(NC1=CC=C(C(F)=C1F)F)=O)C)C2=CC=C3OCCOC3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (657.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6294 mL 13.1468 mL 26.2936 mL
5 mM 0.5259 mL 2.6294 mL 5.2587 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6294 mL 13.1468 mL 26.2936 mL 65.7341 mL
5 mM 0.5259 mL 2.6294 mL 5.2587 mL 13.1468 mL
10 mM 0.2629 mL 1.3147 mL 2.6294 mL 6.5734 mL
15 mM 0.1753 mL 0.8765 mL 1.7529 mL 4.3823 mL
20 mM 0.1315 mL 0.6573 mL 1.3147 mL 3.2867 mL
25 mM 0.1052 mL 0.5259 mL 1.0517 mL 2.6294 mL
30 mM 0.0876 mL 0.4382 mL 0.8765 mL 2.1911 mL
40 mM 0.0657 mL 0.3287 mL 0.6573 mL 1.6434 mL
50 mM 0.0526 mL 0.2629 mL 0.5259 mL 1.3147 mL
60 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0956 mL
80 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.8217 mL
100 mM 0.0263 mL 0.1315 mL 0.2629 mL 0.6573 mL
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IMB-808 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMB-808870768-70-0IMB808IMB 808LXRLiver X receptorLXRβatherosclerosischolesterolABCA1ABCG1Inhibitorinhibitorinhibit

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