1. Metabolic Enzyme/Protease
  2. LXR

AZ876 

Cat. No.: HY-18282 Purity: 99.76%
Handling Instructions

AZ876 is a novel high-affinity LXR agonist.

For research use only. We do not sell to patients.
AZ876 Chemical Structure

AZ876 Chemical Structure

CAS No. : 898800-26-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 406 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively. (1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling. (2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin. (3) The reference for administration is 20 umol/kg/day in vivo.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2750 mL 11.3748 mL 22.7495 mL
5 mM 0.4550 mL 2.2750 mL 4.5499 mL
10 mM 0.2275 mL 1.1375 mL 2.2750 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

439.57

Formula

C₂₄H₂₉N₃O₃S

CAS No.

898800-26-5

SMILES

O=C(C(NC1=CC=C(N2CCCCC2)C=C1)=C3C4=CC=CC=C4)N(C(C)(C)C)S3(=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 2.6 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
AZ876
Cat. No.:
HY-18282
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