Endogenous Metabolite

Related Products

Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health^[1]^[2]^[3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets^[1]^[2]^[3].

References:

[1]. Seyedsayamdost MR. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):301-311.

[2]. Ruiz B, et al. Production of microbial secondary metabolites: regulation by the carbon source. Crit Rev Microbiol. 2010 May;36(2):146-67.

[3]. Wishart DS. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiol Rev. 2019 Oct 1;99(4):1819-1875.

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8492)
Antibodies (477)
Endogenous Metabolite Isoform Comparison

By Effects:	Inhibitors (66) Agonists (3) Controls (2) Antagonist (1) Activators (7) Modulators (9) Chemicals (14) Inducers (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-E70913

Phosphotransacetylase, Bacillus subtilis
Phosphotransacetylase, Bacillus subtilis (EC 2.3.1.8), converts coenzyme A to acetyl-CoA. Phosphotransacetylase is an acyltransferase that transfers groups other than aminoacyl groups. Phosphotransacetylase participates in three metabolic pathways: taurine and hypoturine metabolism, pyruvate metabolism, and propionic acid metabolism.

HY-N10197

Pulixin
Pulixin prevents FREP1 from binding to P. falciparum-infected cell lysate. Pulixin blocks the transmission of the parasite to mosquitoes with an EC₅₀ of 11 µM. Pulixin also inhibits the proliferation of asexual-stage P. falciparum with an EC₅₀ of 47 nM.

HY-106950CS

Fosfructose-1-¹³C sodium
Fosfructose-1-¹³C (sodium) is the ¹³C labeled Fosfructose.

HY-113209A

ent-8-Iso-15(S)-prostaglandin F2α
Ent-8-Iso-15(S)-prostaglandin F2α is an isomer of 8-Isoprostaglandin F2α, with a better inhibiting activity in the whole blood platelet aggregation inhibition assay.

HY-P0206S1

RPP-(Gly-¹³C₂,¹⁵N)-FSPFR TFA
RPP-(Gly-1¹³C₂,¹⁵N)-FSPFR TFA is ¹³C- and ¹⁵N-labeled Bradykinin (HY-P0206). Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.

HY-P2753

Sucrose phosphorylase
Sucrose phosphorylase is a bacterial transglucosidase that catalyzes the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. The glucosylated Sucrose phosphorylase can also be hydrolyzed into α-D-glucose, or transfer the glucoyl to the hydroxyl group of the receptor, and then decomposed into new α-D-glucoside products. The enzymatic activity of base phosphorylase to substrate and product is weak.

HY-W011978S

N-Acetyl-L-tryptophan-d₃
N-Acetyl-L-tryptophan-d₃ is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases.

HY-121883R

Lignoceric acid (Standard)
Lignoceric acid (Standard) is the analytical standard of Lignoceric acid. This product is intended for research and analytical applications. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[1][2].

HY-B2220B

Thermostable cellulase (recombinant)
Thermostable cellulase recombinant is a cellulose hydrolase present in hyperthermophiles, which catalyzes the hydrolysis of β-1,4 glycosidic bonds in cellulose. Thermostable cellulase recombinant targets carboxymethyl cellulose (CMC) as its primary substrate, and retains high residual activity even after incubation at high temperatures. The activity of Thermostable cellulase recombinant is inhibited by ionic and non-ionic detergents, and can be enhanced by cobalt ions. Thermostable cellulase recombinant can be applied in the paper industry.

HY-E70936

Glycerokinase, Streptomyces canus
Glycerokinase, Streptomyces canus (EC 2.7.1.30) is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis. Glycerol kinase catalyzes tge MgATP-dependent phosphorylation of glycerol to produce sn-glycerol-3-phosphate and is the rate limiting enzyme in the utilization of glycerol.

HY-N16402

Aspergillusidone D
Aspergillusidone D (Compound 1), a brominated depsidone, is a Aromatase inhibitor with an IC₅₀ of 0.8  μM. Aspergillusidone D can be isolated from fungus Aspergillus unguis cultured in KBr medium. Aspergillusidone D has potent cytotoxicity against cancers cells, such as MOLT-3 cells. Aspergillusidone D can be used for cancers like breast cancer research.

HY-B0389S41

D-Glucose-²-d₁
D-Glucose-2-d₁ (Glucose-2-d) is the deuterium labeled D-Glucose (HY-B0389). D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the?general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.

HY-16622B

GSK 1842799 hydrochloride
GSK 1842799 hydrochloride is a selective S1P1 receptor agonist with potent agonist activity and exceptional selectivity over S1P3. GSK 1842799 hydrochloride demonstrates good oral bioavailability and rapid conversion to its active phosphorylated form. GSK 1842799 hydrochloride significantly reduces blood lymphocyte counts in vivo following oral administration. GSK 1842799 hydrochloride has shown efficacy comparable to FTY720 in the mouse EAE model of multiple sclerosis.

HY-133186R

Fenamidone (Standard)
Fenamidone (Standard) is the analytical standard of Fenamidone. This product is intended for research and analytical applications. Fenamidone is the active compound.

HY-11084

SNAP-7941
SNAP-7941 is a selective antagonist with anxiolytic, antidepressant and appetite suppressant activities. SNAP-7941 showed promising biological activity in initial animal studies. SNAP-7941 targets the melanin concentrating hormone receptor MCH1 and has significant inhibitory potential. SNAP-7941 was shown to inhibit the centrally induced MCH-induced drinking effect in in vivo studies.

HY-146579S

Estrone-3-glucuronide-d₄ lithium
Estrone-3-glucuronide-d₄ lithium is the deuterium labeled Estrone-3-glucuronide lithium. Estrone 3-glucuronide is a dominant urinary metabolite of?Estradiol?(HY-B0141) and urinary marker for female fertile window prediction. Estrone 3-glucuronide can be used in combination with luteinizing hormone in ovulation prediction kits.

HY-N10293

Monaschromone
Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM.

HY-124489S

2-Hydroxyestradiol-¹³C₆
2-Hydroxyestradiol-¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity.

HY-B0400EGL

D-Sorbitol, M400 (GMP Like)
D-Sorbitol, M400 (GMP Like) is the GMP Like class D-Sorbitol, M400 that can be used as pharmaceutical excipients. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement.

HY-113400

Cytidine 5'-diphosphate
Cytidine 5'-diphosphate (Cytidine diphosphate) is a nucleoside diphosphate that acts as a carrier for phosphorylcholine, diacylglycerol, and other molecules during phospholipid synthesis.

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Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Related Products (8492)

Antibodies (477)

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8492):