2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W723834
    Sodium butyrate-d5
    Sodium butyrate-d5 (Butanoic acid-d5 sodium) is the deuterium labeled Sodium butyrate (HY-B0350A). Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity.
    Sodium butyrate-d<sub>5</sub>
  • HY-D0185S1
    2'-Deoxyguanosine-d monohydrate
    2'-Deoxyguanosine-d (monohydrate) is the deuterium labeled 2'-Deoxyguanosine monohydrate. 2'-Deoxyguanosine monohydrate is an endogenous metabolite.
    2'-Deoxyguanosine-d monohydrate
  • HY-12956S2
    Dinoprost-13C5
    Dinoprost-13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.
    Dinoprost-<sup>13</sup>C<sub>5</sub>
  • HY-E70946
    Adenosine-5'-triphosphate Sulfurylase, Saccharomyces cerevisiae
    Adenosine-5'-triphosphate Sulfurylase, Saccharomyces cerevisiae (EC 2.7.7.4) belongs to the transferase family. Its two substrates are ATP and sulfate, and its two products are diphosphate and adenosine sulfate. Adenosine-5'-triphosphate Sulfurylase, Saccharomyces cerevisiae participates in three metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism.
    Adenosine-5'-triphosphate Sulfurylase, Saccharomyces cerevisiae
  • HY-129509
    Alterporriol B
    Alterporriol B is a red pigment, which can be isolated from Alternaria porri. Alternaria porri is the cause of black spot disease in alliums.
    Alterporriol B
  • HY-B0275S1
    Oxytetracycline-d3
    Oxytetracycline-d3 is the deuterium labeled Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity.
    Oxytetracycline-d<sub>3</sub>
  • HY-P2848B
    Cholesterol Oxidase, Streptomyces sp.
    Cholesterol Oxidase, Streptomyces sp. (EC 1.1.3.6) is a monomeric flavoprotein containing FAD that catalyzes the first step in cholesterol catabolism. This bifunctional enzyme oxidizes cholesterol to cholest-5-en-3-one in an FAD-requiring step, which is then isomerized to cholest-4-en-3-one with the release of H2O2.
    Cholesterol Oxidase, Streptomyces sp.
  • HY-E70891
    β-Galactose Dehydrogenase S, Pseudomonas fluorescens
    β-Galactose Dehydrogenase S, Pseudomonas fluorescens (EC 1.1.1.48) belongs to the oxidoreductase family and is an oxidoreductase that acts on the CH-OH group as a donor and uses NAD+ or NADP+ as an acceptor. β-Galactose Dehydrogenase S, Pseudomonas fluorescens, is involved in galactose metabolism. The enzyme's two substrates are D-galactose and NAD+, while its three products are D-galactonide-1,4-lactone, NADH, and H+.
    β-Galactose Dehydrogenase S, Pseudomonas fluorescens
  • HY-145379
    Miaosporone A
    Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.
    Miaosporone A
  • HY-119618
    R1498
    R1498 is a multi-target kinase inhibitor with anti-angiogenic and anti-proliferative activities. R1498 mainly targets targets such as Aurora kinase and VEGFR2, which are associated with tumor development. R1498 showed moderate in vitro growth inhibition in a variety of tumor cells, with IC50 values in the micromolar range. R1498 showed anti-tumor efficacy superior to sorafenib in a variety of gastric cancer and hepatocellular carcinoma xenograft models, with tumor growth inhibition rates exceeding 80%, and tumor shrinkage was observed in some models. R1498 showed a 10-30% tumor shrinkage rate in three xenograft models derived from human primary gastric cancer tumors, further demonstrating its inhibitory potential. R1498 effectively inhibited Aurora A activity in vivo and reduced tumor vascularization.
    R1498
  • HY-B0350AG
    Sodium butyrate (GMP)
    Sodium butyrate (GMP) refers to Sodium butyrate (HY-B0350A) of GMP grade. Small molecules of GMP grade can be used as adjuvants in cell therapy. Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity.
    Sodium butyrate (GMP)
  • HY-128434R
    L-Leucyl-L-alanine (Standard)
    L-​Leucyl-​L-​alanine (Standard) is the analytical standard of L-​Leucyl-​L-​alanine (HY-128434). This product is intended for research and analytical applications. L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine.
    L-Leucyl-L-alanine (Standard)
  • HY-W011819R
    Tetradecanedioic acid (Standard)
    Tetradecanedioic acid (Standard) is the analytical standard of Tetradecanedioic acid. This product is intended for research and analytical applications. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid is an endogenous biomarker for assessing the activity of organic anion transporting polypeptides (OATPs).
    Tetradecanedioic acid (Standard)
  • HY-135035S
    Decanoyl-L-carnitine-d3
    Decanoyl-L-carnitine ((-)-Decanoylcarnitine)-d3 is deuterium labeled Decanoyl-L-carnitine (HY-135035). Decanoyl-L-carnitine is an endogenous metabolite. Decanoyl-L-carnitine can be used as a serum metabolic biomarkers as indicators in the progression of intravenous leiomyomatosis.
    Decanoyl-L-carnitine-d<sub>3</sub>
  • HY-129319
    Valinotricin
    Valinotricin is a fungal metabolite.
    Valinotricin
  • HY-P1775B
    Carbonic Anhydrase, Human
    Carbonic Anhydrase, Human (EC 4.2.1.1) is a zinc metalloenzyme that catalyzes the hydration of carbon dioxide to form carbonic acid. Carbonic Anhydrase participates in a variety of important physiological processes, such as the maintenance of pH and carbon dioxide homeostasis, the transport of bicarbonate and carbon dioxide, biosynthetic reactions, bone resorption, calcification, and tumorigenesis.
    Carbonic Anhydrase, Human
  • HY-113459S
    Prostaglandin F1a-d9
    Prostaglandin F1a-d9 is the deuterium labeled Prostaglandin F1a. Prostaglandin F1a is an endogenous metabolite and a cyclooxygenase product with platelet activity inhibitory effects. Prostaglandin F1a can be used as a marker in coagulation-related studies.
    Prostaglandin F1a-d<sub>9</sub>
  • HY-101240R
    Propranolol glycol (Standard)
    Propranolol glycol (Standard) is the analytical standard of Propranolol glycol. This product is intended for research and analytical applications. Propranolol glycol is a metabolite of propranolol (HY-B0573B). Propranolol glycol shows instantaneous anticonvulsant activity.
    Propranolol glycol (Standard)
  • HY-113217S1
    Cholesteryl oleate-d7-1
    Cholesteryl oleate-d7-1 is deuterium labeled Cholesteryl oleate. Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing.
    Cholesteryl oleate-d<sub>7</sub>-1
  • HY-N10203
    Rostratin A
    Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC50 of 8.5 μg/mL.
    Rostratin A
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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