Miaosporone A
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells.
For research use only. We do not sell to patients.
- CAS No.: 3039491-16-9
- Formula: C19H18O5
- Molecular Weight:326.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Plasmodium |
Antibacterial 2.5 μM (IC50) |
Microbial Metabolite |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
3.4 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 34748348] |
| NCI-H187 | IC50 |
2.3 μM
Compound: 1
|
Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 34748348] |
| Vero | IC50 |
1.1 μM
Compound: 1
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 34748348] |
Chemical Information
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CAS No. 3039491-16-9
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Molecular Weight 326.34
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Formula C19H18O5
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SMILES
O[C@]12CCC(C(C3=C(C4=O)C=CC=C3O)=O)=C4[C@@]1([H])[C@H](O)C=C(C)C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)