2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. Microtubule/Tubulin

Microtubule/Tubulin

Microtubule/Tubulin

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Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-172611
    Tubulin polymerization-IN-78
    		Inhibitor
    Tubulin polymerization-IN-78 (compound 10a) is a tubulin polymerization inhibitor with an IC50 value of 2.69 μM. Tubulin polymerization-IN-78 shows antiproliferative activity.
    Tubulin polymerization-IN-78
  • HY-N9842
    Violanone
    		Inhibitor
    Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti.
    Violanone
  • HY-123266
    D011-2120
    		Inhibitor
    D011-2120 functions as an antiviral agent by inhibiting microtubule polymerization, disrupting the Golgi complex, and preventing viral trafficking to the plasma membrane during the virus egress process.
    D011-2120
  • HY-N0488S2
    Vincristine-d6 sulfate
    		Inhibitor
    Vincristine-d6 (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas.
    Vincristine-d<sub>6</sub> sulfate
  • HY-162667
    EX05
    		Inhibitor
    EX05 is a potent KIF18A inhibitor with an IC50 value of 8.2 nM. EX05 has the potential for the research of cancer.
    EX05
  • HY-147848
    Tubulin polymerization-IN-27
    		Inhibitor
    Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis.
    Tubulin polymerization-IN-27
  • HY-106399A
    Acodazole hydrochloride
    		Inhibitor
    Acodazole hydrochloride is an anticancer agent that exerts its anticancer activity by inhibiting microtubule polymerization.
    Acodazole hydrochloride
  • HY-130273
    HDAC/HSP90-IN-1
    		Inhibitor
    HDAC/HSP90-IN-1 (compound 20) is a potent dual inhibitor of HDAC (IC50 = 194 nM) and HSP90 (HSP90α IC50 = 153 nM). HDAC/HSP90-IN-1 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-1 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-1 can be used for cancer research, such as lung and colon cancer.
    HDAC/HSP90-IN-1
  • HY-171680
    Anti-CCL2 (Carlumab)-SMCC-DM1
    		Inhibitor
    Anti-CCL2 (Carlumab)-SMCC-DM1 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the linker SMCC (HY-42360) and the cytotoxic microtubule inhibitor DM1 (HY-19792). The ADC toxic molecule and linker part are SMCC-DM1 (HY-101070). Anti-CCL2 (Carlumab)-SMCC-DM1 can be used in the research of cancer, especially prostate cancer.
    Anti-CCL2 (Carlumab)-SMCC-DM1
  • HY-115941
    HDAC-IN-9
    		Inhibitor
    HDAC-IN-9 is a potent and selective tubulin and HDAC dual inhibitor. HDAC-IN-9 inhibits the invasion and migration of A549 cells. HDAC-IN-9 shows potent antitumor and antiangiogenic effect in vitro and in vivo.
    HDAC-IN-9
  • HY-139105
    20-O-Demethyl-AP3
    		Inhibitor
    20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. Ansamitocin P-3, a microtubule inhibitor, is a macrocyclic antitumor antibiotic.
    20-O-Demethyl-AP3
  • HY-119169
    Tubulozole
    		Inhibitor
    Tubulozole is an orally active synthetic microtubule inhibitor. Tubulozole can be used for the research of tumor.
    Tubulozole
  • HY-16371
    Ortataxel
    		Inhibitor
    Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines.
    Ortataxel
  • HY-N16507
    Bruceoside D
    		Inhibitor
    Bruceoside D is a cytotoxic quassinoid glucoside found in Brucea javanica. Bruceoside D is a microtubule polymerization inhibitor. Bruceoside D demonstrates inhibitory activity against leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3) cell lines. Bruceoside D is promising for research of cancers.
    Bruceoside D
  • HY-118385
    ER-67880
    		Inhibitor
    ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma.
    ER-67880
  • HY-157850
    BP-M345
    		Inhibitor
    BP-M345 (compound 5) is a potent, cancer cell-targeting antiproliferative agent that exhibits low toxicity to non-tumor cells. BP-M345 inhibits cancer cell proliferation with a GI50 value ranging from 0.17 to 0.45 μM.
    BP-M345
  • HY-176201
    Tubulin polymerization-IN-80
    		Inhibitor
    Tubulin polymerization-IN-80 (Compound 32) is a potent tubulin polymerization inhibitor with antiproliferative activity. Tubulin polymerization-IN-80 disrupts microtubule formation and leads to cell cycle arrest and apoptosis. Tubulin polymerization-IN-80 is promising for research of cancers.
    Tubulin polymerization-IN-80
  • HY-115956
    Tubulin inhibitor 18
    		Inhibitor
    Tubulin inhibitor 18 (compound 5j) is a potent inhibitor of tubulin. Tubulin inhibitor 18 is a chalcone compound. Tubulin inhibitor 18 has the potential for the research of cancer diseases.
    Tubulin inhibitor 18
  • HY-181491
    Tubulin-IN-64
    		Inhibitor
    Tubulin-IN-64 is a sulfonated styrylquinazoline derivative with high selectivity antitumor activity. Tubulin-IN-64 targets tubulin, inhibits the EGFR/Akt/mTOR and EGFR/Ras signaling pathways, induces cell cycle arrest, apoptosis and autophagy. Tubulin-IN-64 exhibits significant antitumor efficacy in the zebrafish GBM xenograft model. Tubulin-IN-64 can be used for the research on glioblastoma and leukemia.
    Tubulin-IN-64
  • HY-155350
    Tubulin polymerization-IN-53
    		Inhibitor
    Tubulin polymerization-IN-53 (compound 4b) is an inhibitor of β-tubulin polymerization. Tubulin polymerization-IN-53 can arrest the cell cycle at the G2/M stage. Tubulin polymerization-IN-53 has antiproliferative efficacy against the MDA-MB-231 cell line with an IC50 value of 3.24 μM.
    Tubulin polymerization-IN-53
Cat. No. Product Name / Synonyms Application Reactivity