2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease Cytoskeleton Immunology/Inflammation
  3. HDAC HSP Microtubule/Tubulin PD-1/PD-L1
  4. HDAC/HSP90-IN-1

HDAC/HSP90-IN-1 (compound 20) is a potent dual inhibitor of HDAC (IC50 = 194 nM) and HSP90 (HSP90α IC50 = 153 nM). HDAC/HSP90-IN-1 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-1 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-1 can be used for cancer research, such as lung and colon cancer.

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HDAC/HSP90-IN-1

HDAC/HSP90-IN-1 Chemical Structure

CAS No. : 2244714-37-0

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HDAC/HSP90-IN-1 Related Antibodies

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Description

HDAC/HSP90-IN-1 (compound 20) is a potent dual inhibitor of HDAC (IC50 = 194 nM) and HSP90 (HSP90α IC50 = 153 nM). HDAC/HSP90-IN-1 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-1 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-1 can be used for cancer research, such as lung and colon cancer[1].

IC50 & Target[1]

HDAC

194 nM (IC50)

HSP90α

153 nM (IC50)

HSP70

 

Molecular Weight

471.55

Formula

C25H33N3O6
CAS No.
SMILES

O=C(NC1=CC=C(N(C(C2=CC(C(C)C)=C(O)C=C2O)=O)C)C=C1)CCCCCCC(NO)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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HDAC/HSP90-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC/HSP90-IN-12244714-37-0HDACHSPMicrotubule/TubulinPD-1/PD-L1Histone deacetylasesHeat shock proteinsPD-1/Programmed death-ligand 1HSP70 expressionHSP90 client proteinsα tubulinIFN-γ treated H1975 cellsInhibitorinhibitorinhibit

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