HDAC-IN-9
HDAC-IN-9 is a potent and selective tubulin and HDAC dual inhibitor. HDAC-IN-9 inhibits the invasion and migration of A549 cells. HDAC-IN-9 shows potent antitumor and antiangiogenic effect in vitro and in vivo.
For research use only. We do not sell to patients.
- Formula: C33H38N2O4
- Molecular Weight:526.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 6.8 μM (IC50) |
HDAC2 0.06 μM (IC50) |
HDAC6 0.12 μM (IC50) |
HDAC8 8.5 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.78 μM
Compound: 17
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 38823265] |
| U-937 | IC50 |
0.371 μM
Compound: 17
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Cytotoxicity against human U-937 cells
Cytotoxicity against human U-937 cells
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[PMID: 38823265] |
HDAC-IN-9 (compound 4s) shows anti-proliferative activity (IC50s of 1.821, 2.538, 4.84, 1.782, 2.525, 0.371 µM for MCF-7, MGC-803, HeLa, A549, HepG2, U937 cells, respectively)[1].
HDAC-IN-9 displays 6.1, 3.2 and 4.6-fold selectivity ratios for 293 T, macrophages, and L02 cells respectively (IC50s of 10.89, 5.63, 8.14 µM for 293 T, macrophages, and L02 cells, respectively)[1].
HDAC-IN-9 shows inhibition activities against HDAC isoforms (IC50s of 6.8, 0.06, 0.12, 8.5 µM for HDAC 1, HDAC 2, HDAC 6, HDAC 10, respectively)[1].
HDAC-IN-9 (1, 2, 4 µM; 72 h; A459 cells) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner[1].
HDAC-IN-9 (1, 2, 4 µM; 72 h) induces apoptosis via a Caspase-dependent intrinsic mitochondrial-mediated pathway in A549 cells[1].
HDAC-IN-9 (0, 0.5, 1, 2 µM; 48 h) shows anti-proliferative activity by the inhibition of angiogenesis and the reduction of endothelial cell metastasis in A549 cells[1].
HDAC-IN-9 (0, 1, 2, 4 µM, 48 h) inhibits the invasion and migration of A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MGC-803, HeLa, A549, HepG2, U937 cells
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Concentration:
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Incubation Time:72 h
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Result:Showed anti-proliferative activity (IC50s of 1.821, 2.538, 4.84, 1.782, 2.525, 0.371 µM for MCF-7, MGC-803, HeLa, A549, HepG2, U937 cells, respectively).
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Cell Line:A459 cells
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Concentration:0, 1, 2, 4 µM
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Incubation Time:72 h
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Result:Cells were arrested at the G2/M phase with a dose-dependent manner.
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Cell Line:A459 cells
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Concentration:0, 1, 2, 4 µM
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Incubation Time:72 h
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Result:Induced apoptosis via a Caspase-dependent intrinsic mitochondrial-mediated pathway in A549 cells.
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Cell Line:A459 cells
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Concentration:0, 1, 2, 4 µM
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Incubation Time:72 h
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Result:Showed down regulation of Cyclin B1 and Pcdc2 levels.
HDAC-IN-9 (0, 2.5, 5, 10 µM; 3 days) inhibits the proliferation and metastasis of A549 cells in zebrafish xenograft models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:embryos of Tg(flk:EGFP) transgenic zebrafish (transgenic zebrafish model Tg(flk1:EGFP))[1]
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Dosage:0, 10, 20, 40 µM
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Administration:
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Result:Suppressed the formation of ISVs in zebrafish embryos.
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Animal Model:zebrafish xenograft models[1]
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Dosage:0, 2.5, 5, 10 µM
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Administration:3 days
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Result:Inhibited the proliferation and metastasis of A549 cells in zebrafish xenograft models.
Chemical Information
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Molecular Weight 526.67
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Formula C33H38N2O4
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SMILES
[H][C@]12CC[C@@]3([C@H](CC[C@]3([C@@]1(CCC4=CC(OCC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=C(C=C42)OC)[H])[H])O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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