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Cat. No.: HY-118385

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ER-67880

ER-67880 is a potent microtubule inhibitor with an IC₅₀ of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC₅₀s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma.

For research use only. We do not sell to patients.

CAS No.: 247186-96-5
Formula: C₁₅H₁₃ClN₂O₃S
Molecular Weight:336.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

ER-67880 Chemical Structure

CAS No.: 247186-96-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.37 μM Compound: 5	Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line	[PMID: 12383017]
HCT-116	IC₅₀	2.2 μM Compound: 5	Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 -C1cell line	[PMID: 12383017]
KB	IC₅₀	0.55 μg/mL Compound: 16	Antiproliferative activity against KB human nasopharynx carcinoma in vitro Antiproliferative activity against KB human nasopharynx carcinoma in vitro	[PMID: 10508428]
KB	IC₅₀	0.55 μg/mL Compound: 3	In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay In vitro antiproliferative activity (4 ug/mL) was measured against KB cancer cell line using MTT colorimetric assay	[PMID: 10866386]
MC-38	IC₅₀	0.2 μg/mL Compound: 16	In vitro antiproliferative activity against colon 38 murine adenocarcinoma In vitro antiproliferative activity against colon 38 murine adenocarcinoma	[PMID: 10508428]
MC-38	IC₅₀	0.2 μg/mL Compound: 3	In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay In vitro antiproliferative activity (4 ug/mL) was measured against colon 38 cancer cell line using MTT colorimetric assay	[PMID: 10866386]
P388	IC₅₀	0.76 μg/mL Compound: 16	Antiproliferative activity against P388 murine leukemia in vitro Antiproliferative activity against P388 murine leukemia in vitro	[PMID: 10508428]
P388	IC₅₀	0.76 μg/mL Compound: 3	In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay In vitro antiproliferative activity (4 ug/mL) was measured against P388 cancer cell line using MTT colorimetric assay	[PMID: 10866386]
P388	IC₅₀	1.2 μM Compound: 5	Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line	[PMID: 12383017]
P388	IC₅₀	1.2 μM Compound: 5	Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line	[PMID: 12383017]

Chemical Information

CAS No. 247186-96-5
Molecular Weight 336.79
Formula C₁₅H₁₃ClN₂O₃S
SMILES

O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Owa T. Chemistry and Biology of a Series of Antitumor Sulfonamides Exploiting Transcriptomic and Quantitative Proteomic Analyses for Exploring Druggable Chemical Space. Journal of Synthetic Organic Chemistry, Japan. 2006 Nov 1;64(11):1171-9.

[2]. Owa T, et al. Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. J Med Chem. 2002 Oct 24;45(22):4913-22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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