247186-96-5
Chemical Structure
ER-67880
- CAS No.: 247186-96-5
- Formula:C15H13ClN2O3S
- Molecular Weight:336.79
IUPAC Name: N-(3-chloro-1H-indol-7-yl)-4-methoxybenzenesulfonamide
InChIKey: UEIFSFBNRBJSCK-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C=C1)OC)(NC2=CC=CC3=C2NC=C3Cl)=O
Biological Activity:
ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma[1][2].
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ER-67880 | ER-67880 is a potent microtubule inhibitor with an IC50 of 9.5 μM. ER-67880 exhibits anti-proliferative activity against KB, Colon 38 and P338 cells with IC50s of 0.55, 0.2 and 0.76 μg/mL. ER-67880 causes G2/M phase arrest and is accompanied by abnormal DNA replication. ER-67880 exhibits a down-regulation pattern of G1 phase-related genes. ER-67880 can be used in various cancer studies, including those of nasopharyngeal carcinoma and murine adenocarcinoma. |
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- [1]. Owa T. Chemistry and Biology of a Series of Antitumor Sulfonamides Exploiting Transcriptomic and Quantitative Proteomic Analyses for Exploring Druggable Chemical Space. Journal of Synthetic Organic Chemistry, Japan. 2006 Nov 1;64(11):1171-9.
- [2]. Owa T, et al. Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide and N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide. J Med Chem. 2002 Oct 24;45(22):4913-22. [Content Brief]
Keywords
