NO Synthase Inhibitor

NO Synthase Inhibitors (651):

Cat. No.	상품명	효과	Purity

HY-182236

JRN73958	Inhibitor
JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia.

HY-138454

MEG hemisulfate	Inhibitor
MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC₅₀s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock.

HY-N0589S

Dehydrodiisoeugenol-d₄	Inhibitor
Dehydrodiisoeugenol-d₄ is the deuterium labeled Dehydrodiisoeugenol (HY-N0589). Dehydrodiisoeugenol is an orally active anti-inflammatory and anti-tumor agent. Dehydrodiisoeugenol inhibits the proliferation of colorectal cancer cells, and induces apoptosis, autophagy, endoplasmic reticulum stress and cell cycle arrest. Dehydrodiisoeugenol also exerts anti-inflammatory effects by inhibiting the activation of NF-κB and the expression of COX-2. Dehydrodiisoeugenol can be used in the research related to colorectal cancer, inflammatory diseases and ulcerative colitis.

HY-N12478

Ainsliadimer A	Inhibitor
Ainsliadimer A is a sesquiterpene lactone dimer with an unusual carbon skeleton. Ainsliadimer A can be obtained from from Ainsliaea macrocephala. Ainsliadimer A inhibits the production of nitric oxide in cells stimulated by LPS.

HY-N16774

Balanophonin B	Inhibitor
Balanophonin B is a selective inhibitor (IC₅₀=1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Lithocarpus pachylepis. Balanophonin B inhibits the production of NO in LPS-stimulated RAW264.7 macrophages and exerts anti-inflammatory activity to reduce the inflammatory response. Balanophonin B can be used for anti-inflammatory drug development and biological activity research of natural lignan compounds.

HY-18252R

Avanafil (Standard)	Inhibitor
Avanafil (Standard) is the analytical standard of Avanafil. This product is intended for research and analytical applications. Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis.

HY-173410

iNOs-IN-6	Inhibitor
iNOs-IN-6 is an anti-inflammatory agent. iNOs-IN-6 inhibits NF-κB, iNOS, and MAPK expression(IC₅₀: 0.2-0.62 μM). iNOs-IN-6 reduces IL-6, TNF-α, and IL-1β pro-inflammatory mediators levels (IC₅₀: 0.4-0.69 μM).

HY-161396

Anti-inflammatory agent 76	Inhibitor
Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, IL-1β and IL-6 inhibitory activities.

HY-N16817

Rabdoternin E	Inhibitor
Rabdoternin E is a potential anti-inflammatory and antitumor agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC₅₀=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC₅₀ values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus).

HY-N15503

Cycloneroside B	Inhibitor
Cycloneroside B is a novel sesquiterpene aminoglycoside compound that can be isolated from Trichoderma sp. SCSIOW21. Cycloneroside B has the activity of inhibiting the production of NO, and its IC₅₀ value for inhibiting the production of NO is 50.7 µM. Cycloneroside B can be used in the research of the anti-inflammatory field.

HY-W032938

COX-1-IN-4	Inhibitor
COX-1-IN-4 (Compound P10) is a selective COX-1 inhibitor (IC₅₀s: COX-1 = 0.09 μM; COX-2 = 2.49 μM). COX-1-IN-4 reduces the production of NO as well as the expression of the iNOS protein. COX-1-IN-4 can be used in the research of neuroinflammation.

HY-N2053

Physalin L	Inhibitor
Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity.

HY-156241

Meliadubin B	Inhibitor
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC₅₀ of 182.50 μM.

HY-N17496

Cyathisterol	Inhibitor
Cyathisterol is a steroidal compound that inhibits LPS (HY-D1056)-induced nitric oxide production. Cyathisterol can be used for the research of inflammatory diseases.

HY-14343

KLYP961	Inhibitor
KLYP961 is a selective and orally active dual inhibitor of inducible and neuronal NO synthase (IC₅₀ = 50-400 nM). KLYP961 can inhibit endotoxin-evoked plasma nitrates increases and attenuate pain behaviors in a mouse formalin model. KLYP961 can attenuate carrageenin-induced edema and inflammatory hyperalgesia and writhing response elicited by Phenylbenzoquinone (HY-W275039). KLYP961 can be used for the research of neurological disease.

HY-161513

iNOS/COX-2-IN-1	Inhibitor
iNOS/COX-2-IN-1 (Compound 12e) is an inhibitor of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). iNOS/COX-2-IN-1 inhibits the NF-κB and MAPKs signaling pathways and thus exerts anti-inflammatory effects.

HY-181642

nNOS-IN-3	Inhibitor
nNOS-IN-3 (compound 4) is an orally active, selective, neuronal nitric oxide synthase (nNOS) inhibitor with a human hnNOS K_i of 25 nM, rat rnNOS K_i of 18 nM, human heNOS K_i of 58140 nM, human hiNOS K_i of 6422 nM. nNOS-IN-3 binds to nNOS active sites via hydrogen bonds with Glu and chalcogen bonds with Met, fails to form chalcogen bonds with heNOS, and undergoes passive transcellular transport with minimal efflux liability. nNOS-IN-3 can be used for the research of neurodegenerative diseases and melanoma.

HY-114798

Rabelomycin	Inhibitor
Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀ of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease.

HY-146421

Anti-inflammatory agent 21	Inhibitor
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC₅₀ value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.

HY-N0152R

Myricitrin (Standard)	Inhibitor
Myricitrin (Standard) is the analytical standard of Myricitrin. This product is intended for research and analytical applications. Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects.

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