Rabelomycin

Cat. No.: HY-114798: Data Sheet Handling Instructions
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Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀ of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease.

For research use only. We do not sell to patients.

Rabelomycin Chemical Structure

CAS No. : 28399-50-0

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

iNOS

63.9 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	4.28 μM Compound: 8	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 23136829]
NCI-H460	IC₅₀	9.91 μM Compound: 8	Cytotoxicity against human NCI-H460 cells by SRB assay Cytotoxicity against human NCI-H460 cells by SRB assay	[PMID: 23136829]
SF-268	IC₅₀	5.54 μM Compound: 8	Cytotoxicity against human SF268 cells by SRB assay Cytotoxicity against human SF268 cells by SRB assay	[PMID: 23136829]

In Vitro

Rabelomycin (100-10 mM; 30 minutes) dose-dependently inhibits partially purified iNOS enzyme from RAW 264.7 macrophage cell lysate with an IC₅₀ of 63.9 μM^[1].
Rabelomycin inhibits the growth of Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus thuringiensis SCSIO BT01 and Bacillus subtilis SCSIO BS01, with MICs of 16 μg/mL, 1 μg/mL, 8 μg/mL and 16 μg/mL, respectively^[3].
Rabelomycin inhibits the growth of SF-268, MCF-7, and NCI-H460 cells, with IC₅₀ values of 5.54 μM, 4.28 μM, and 9.91 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

338.31

Formula

C₁₉H₁₄O₆

CAS No.

28399-50-0

SMILES

O=C1C2=C(C[C@@](O)(C1)C)C=C(O)C(C(C3=C(O)C=CC=C34)=O)=C2C4=O

Structure Classification

Initial Source

Microorganisms

Streptomyces sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alvi KA, et al. Identification of inhibitors of inducible nitric oxide synthase from microbial extracts. J Antibiot (Tokyo). 2000;53(5):496-501. [Content Brief]

[2]. Yang K, et al. Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae. Microbiology (Reading). 1996;142 ( Pt 1):123-132.

[3]. Zhang W, et al. Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160. J Nat Prod. 2012 Nov 26;75(11):1937-43. [Content Brief]

Rabelomycin Related Classifications

Neurological Disease Infection

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The dilution calculator equation

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rabelomycin28399-50-0AntibioticBacterialNO SynthaseNitric oxide synthasesNOSjadomycin BcitrullineORF6-disrupted Streptomyces venezuelae mutantsRAW 264.7 macrophage cell lysateinducible nitric oxide synthaseStreptomyces venezuelae VS655a/b mutantsiNOSnitric oxideL-arginineInhibitorinhibitorinhibit

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