28399-50-0
28399-50-0
Chemical Structure
Rabelomycin
- CAS No.: 28399-50-0
- Formula:C19H14O6
- Molecular Weight:338.31
IUPAC Name: (R)-3,6,8-trihydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione
InChIKey: JJOLHRYZQSDLSA-LJQANCHMSA-N
SMILES: O=C1C2=C(C[C@@](O)(C1)C)C=C(O)C(C(C3=C(O)C=CC=C34)=O)=C2C4=O
Biological Activity: Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease[1][2].
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Rabelomycin | Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease. | |||||||||||||||||||||
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References
- [1]. Alvi KA, et al. Identification of inhibitors of inducible nitric oxide synthase from microbial extracts. J Antibiot (Tokyo). 2000;53(5):496-501. [Content Brief]
- [2]. Yang K, et al. Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae. Microbiology (Reading). 1996;142 ( Pt 1):123-132. [Content Brief]
Keywords
