Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
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Phosphatase Inhibitors
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Phosphatase Agonists
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Phosphatase Antagonists
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Phosphatase Activators
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Phosphatase Modulators
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Phosphatase Chemical
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Phosphatase Inducers
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Phosphatase Degraders
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Phosphatase Controls
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Phosphatase Substrates
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Phosphatase Ligands
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Phosphatase Proteins
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Phosphatase Related Products (712)
Related Products (712)
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Recombinant Proteins (66)
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Antibodies (40)
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Related Compound Screening Libraries (1)
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(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
0 ImagesCat. No.: HY-116748CAS No.: 257641-01-3(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research.
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PTP1B-IN-25
0 ImagesCat. No.: HY-163463PTP1B-IN-25 (Compound 19) is a PTP1B inhibitor with remarkable antiviral, antibacterial, and antidiabetic activities. PTP1B-IN-25 has IC50 values of 0.37 μM, 8.6 μM, 3.7 μM, and 29 μM against PTP1B, HIV, α-Glucosidase, and methicillin-resistant Staphylococcus aureus (MRSA) respectively.
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IP2
0 ImagesCat. No.: HY-144655CAS No.: 2247640-44-2
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FTY720-Mitoxy
0 ImagesCat. No.: HY-135284CAS No.: 1604816-11-6FTY720-Mitoxy is a fingolimod hydrochloride (HY-12005) derivative with neuroprotective and PP2A activating activities. FTY720-Mitoxy has the property of targeting mitochondria. In addition, FTY720-Mitoxy protects neurons by reducing inflammatory responses and is used in the study of neurodegenerative diseases such as Parkinson's disease.
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Karanjin (Standard)
0 ImagesKaranjin (Standard) is the analytical standard of Karanjin. This product is intended for research and analytical applications. Karanjin is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research.
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Dibefurin
0 ImagesCat. No.: HY-N10186CAS No.: 175448-33-6Dibefurin is a fungal metabolite that acts as an inhibitor of calcineurin phosphatase.
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Loganic acid (Standard)
0 ImagesCat. No.: HY-N0513RCAS No.: 22255-40-9Loganic acid (Standard) is the analytical standard of Loganic acid. This product is intended for research and analytical applications. Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active.
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VHR-IN-7
0 ImagesCat. No.: HY-178297CAS No.: 1146616-17-2VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.47 μM), CD45 (IC50 = 0.3 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 0.59 μM), and HePTP (IC50 = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer.
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Trimegestone
0 ImagesCat. No.: HY-106827CAS No.: 74513-62-5Synonyms: RU 27987Trimegestone (RU 27987) is an orally active, selective progestogen and PR ligand, with an IC50 of 7.6 nM for hPR, 4.4 nM for rabbit PR, and 3.3 nM for rat PR. Trimegestone induces Alkaline phosphatase activity. Trimegestone exhibits antiandrogenic activity (IC50 = 303 nM). Trimegestone can be used in research related to menopausal symptoms and osteoporosis.
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PTP1B-IN-19
0 ImagesCat. No.: HY-144716CAS No.: 2848581-83-7PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.
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(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
0 ImagesCat. No.: HY-N1783CAS No.: 329975-47-5(24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor, with an IC50 of 0.4 μM. (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid exhibits potent PTP1B inhibitory activity without cytotoxicity.
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PTPN2 ligand 1
0 ImagesCat. No.: HY-168691CAS No.: 3032975-34-8PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760).
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Phosphatase, Escherichia coli
0 ImagesCat. No.: HY-E70914Phosphatase, Escherichia coli (EC 3.1.3.-) is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group.
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Antidiabetic agent 2
0 ImagesCat. No.: HY-155961CAS No.: 3052242-32-4Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase with IC50s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels.
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Phosphatase Binder-1
0 ImagesCat. No.: HY-156970CAS No.: 2456385-41-2Phosphatase Binder-1 (comppund i-196) provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Phosphatase Binder-1 plays an important role in cancer.
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LXQ-87
0 ImagesCat. No.: HY-168706CAS No.: 2524718-73-6LXQ-87 is an oral noncompetitive inhibitor of PTP1B with an IC50 of 1.061 μM, showing hypoglycemic activity. LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake, making it useful for research on type 2 diabetes.
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(E/Z)-Icerguastat acetate
0 ImagesCat. No.: HY-18956BCAS No.: 469866-31-7Synonyms: (E/Z)-Sephin1 acetate; (E/Z)-IFB-088 acetate(E/Z)-Icerguastat ((E/Z)-Sephin1) acetate is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat acetate can be used for protein misfolding diseases research.
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WVSAV
0 ImagesCat. No.: HY-P10671WVSAV is a ligand of the PDZ2 domain (Tyrosine Phosphatase) with a Kd value of 111 μM. WVSAV can be used for binding studies in the field of protein-ligand interactions.
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Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard
0 ImagesSynonyms: Potassium phosphate monobasic (Pharmaceutical primary standard, USP)Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard (Potassium phosphate monobasic (Pharmaceutical primary standard, USP)) is a potassium salt. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard activates NF-κB. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard upregulates the expression of dental/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) and enhances the mineralization capacity of human periodontal ligament stem cells. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard promotes the proliferation of human periodontal ligament stem cells in logarithmic growth phase. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard promotes the growth of somatic embryos of Dendrobium Sonia, increases leaf number, leaf length and fresh weight of tissue-cultured seedlings. Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard is applicable to periodontal disease-related research.
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L-671776
0 ImagesCat. No.: HY-117672CAS No.: 134313-74-9L-671776 can be isolated from a fungal strain (ATCC 20928B), is a non-competitive inhibitor of IMPase.
