2. シグナル伝達
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

製品番号 製品名 製品効果 純度 構造式
  • HY-168706
    LXQ-87 Inhibitor
    LXQ-87 is an oral noncompetitive inhibitor of PTP1B with an IC50 of 1.061 μM, showing hypoglycemic activity. LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake, making it useful for research on type 2 diabetes.
    LXQ-87
  • HY-126390
    (E/Z)-BCI Inhibitor 99.38%
    (E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.
    (E/Z)-BCI
  • HY-18956B
    (E/Z)-Icerguastat acetate Inhibitor
    (E/Z)-Icerguastat ((E/Z)-Sephin1) acetate is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat acetate can be used for protein misfolding diseases research.
    (E/Z)-Icerguastat acetate
  • HY-P10671
    WVSAV
    WVSAV is a ligand of the PDZ2 domain (Tyrosine Phosphatase) with a Kd value of 111 μM. WVSAV can be used for binding studies in the field of protein-ligand interactions.
    WVSAV
  • HY-117672
    L-671776 Inhibitor
    L-671776 can be isolated from a fungal strain (ATCC 20928B), is a non-competitive inhibitor of IMPase.
    L-671776
  • HY-E70932
    Non-Prostatic Acid Phosphatase, Sweet Potato
    Non-Prostatic Acid Phosphatase, Sweet Potato (EC 3.1.3.2), a type of enzyme, used to free attached phosphoryl groups from other molecules during digestion. Acid phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum. This enzyme is present in many animal and plant species.
    Non-Prostatic Acid Phosphatase, Sweet Potato
  • HY-123960B
    (E/Z)-Raphin1 Inhibitor
    (E/Z)-Raphin1 is an inhibitor of PPP1R15B, a regulatory subunit of protein phosphatase 1. (E/Z)-Raphin1 is orally available and can cross the blood-brain barrier. (E/Z)-Raphin1 can be used in neurological research.
    (E/Z)-Raphin1
  • HY-B0307A
    Idoxuridine hydrate Inhibitor
    Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM.
    Idoxuridine hydrate
  • HY-106417
    Limazocic Inhibitor
    Limazocic (SA 3443) is an orally active hepatoprotective agent. Limazocic can inhibit increases in serum transaminase, alkaline phosphatase activity and hepatic lipids, hydroxyproline content induced by CCl4. Limazocic can decrease the degree of hepatic necrosis, fibrosis and steatosis. Limazocic can be used for the research of chronic liver injuries.
    Limazocic
  • HY-B2006S
    Fenvalerate-d5 Inhibitor
    Fenvalerate-d5 is the deuterium labeled Fenvalerate. Fenvalerate is a potent protein phosphatase 2B (calcineurin) inhibitor with an IC50 of 2-4 nM for PP2B-Aα. Fenvalerate is a pyrethroid ester insecticide and acaricide.
    Fenvalerate-d<sub>5</sub>
  • HY-P991793
    Anti-Rat CD45RC Antibody (OX22) Inhibitor
    Anti-Rat CD45RC Antibody (OX22) reacts with rat CD45RC. CD45RC molecule is involved in lymphocyte signaling and is associated with inflammatory responses. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-Rat CD45RC Antibody (OX22)
  • HY-169002
    PP5-IN-2 Inhibitor
    PP5-IN-2 is an orally active and selective protein phosphatase 5 (PP5) inhibitor with an IC50 value of 0.9 μM. PP5-IN-2 activates p53 and downregulates cyclin D1 and MGMT, which shows potency in cell cycle arrest and reverses Temozolomide (TMZ) (HY-17364) resistance in the U87 MG cell line. PP5-IN-2 effectively inhibits tumor growth in the xenograft mouse model.
    PP5-IN-2
  • HY-149255
    PTP1B/AKR1B1-IN-2 Inhibitor
    PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM).
    PTP1B/AKR1B1-IN-2
  • HY-N13813
    Ethyl-3,5-di-O-caffeoylquinate Control
    Ethyl-3,5-di-O-caffeoylquinate is an ethyl caffeoylquinate (ECQ), and ECQ analogs are potential α-glucosidase (α-glucosidase) inhibitors and PTP1B inhibitors. Ethyl-3,5-di-O-caffeoylquinate, which can be isolated from the flower buds of Lonicera macranthoides, is an isomer of chlorogenic acid (ethyl dicaffeoylquinate).
    Ethyl-3,5-di-O-caffeoylquinate
  • HY-126730
    Rubratoxin A Inhibitor
    Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A) with an IC50 of 170 nM. Rubratoxin A causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.
    Rubratoxin A
  • HY-155037
    VE-PTP-IN-1
    VE-PTP-IN-1 (compound 2) is a weakly acidic and selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP).VE-PTP-IN-1 is assocaited with vascular homeostasis and angiogenesis.
    VE-PTP-IN-1
  • HY-N10648
    PTP1B-IN-20 Inhibitor
    PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition.
    PTP1B-IN-20
  • HY-178292
    VHR-IN-3 Inhibitor
    VHR-IN-3 (Compound 1) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with a Ki of 0.81 μM. VHR-IN-3 mimics the phosphate group through the sulfonic acid group and competitively binds to the catalytic active center of VHR. VHR-IN-3 can be used for the research of cervical cancer.
    VHR-IN-3
  • HY-13723R
    Pimecrolimus (Standard) Inhibitor
    Pimecrolimus (Standard) is the analytical standard of Pimecrolimus. This product is intended for research and analytical applications. Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity.
    Pimecrolimus (Standard)
  • HY-111489
    LMPTP inhibitor 1 Inhibitor
    LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
    LMPTP inhibitor 1
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