2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Phosphatase
  4. Idoxuridine hydrate

Idoxuridine hydrate  (Synonyms: 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate)

Cat. No.: HY-B0307A
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Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM.

For research use only. We do not sell to patients.

CAS No. : 17140-71-5

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Idoxuridine hydrate Related Antibodies

Top Publications Citing Use of Products

    Idoxuridine hydrate purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jan 9:2025.01.09.632184.  [Abstract]

    Bottom: RNF25+/+ and RNF25−/− Pa02C and Pa03C cells were labeled with CldU and Idoxuridine (IdU) (250 μM) and fork speed was calculated by dividing tract lengths by total pulse time.

    Idoxuridine hydrate purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Jan 9:2025.01.09.632184.  [Abstract]

    Top: Schematic of fork degradation assays. Bottom: RNF25+/+ and RNF25−/− Pa02C and Pa03C cells were labeled with CldU and Idoxuridine (IdU) (250 μM), then treated with HU to induce fork stalling. The ratio of IdU to CldU tracts was used as a readout of fork degradation.

    Idoxuridine hydrate purchased from MedChemExpress. Usage Cited in: Emerg Microbes Infect. 2023 Dec;12(1):2208682.  [Abstract]

    The cytotoxicity test results of the drug showed that the CC50 of Tecovinimat was 21.95 μM, the CC50 of Idoxuridine was 18.33 μM, the CC50 of Brincidofovir was 17.87 μM, and the CC50 of Cidovir > 200 μM.

    Idoxuridine hydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2020 Apr;39(14):2905-2920.  [Abstract]

    Representative images of CIdU and Idoxuridine (IdU, 25 μM, 30 μM) positive PC-3 cells (scale bar: 25 μm).

    Idoxuridine hydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2020 Apr;39(14):2905-2920.  [Abstract]

    The percentage of CIdU and Idoxuridine (IdU, 25 μM, 30 μM) positive cells in three wells.

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    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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    Description

    Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1].

    IC50 & Target

    DNA Polymerase

     

    In Vitro

    Idoxuridine (2-10 μM, 72 hours) hydrate has the IC50 value of 4.3 μM of antiviral[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Idoxuridine hydrate Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: Crandell-Reese feline kidney (CRFK) cells
    Concentration: 2-10 μM
    Incubation Time: 72 hours
    Result: Showed the IC50 value of 4.3 μM.

    Cell Cytotoxicity Assay[1]

    Cell Line: Crandell-Reese feline kidney (CRFK) cells
    Concentration: 5-50 μM
    Incubation Time: 72 hours
    Result: Reduced by 10.8% relatively in CRFK cells.
    In Vivo

    Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months[2]
    Dosage: 50-200 mg/kg
    Administration: Intraperitoneal injection, 3 times, 3 hours interval
    Result: Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.
    Clinical Trial
    Molecular Weight

    372.11

    Formula

    C9H13IN2O6
    CAS No.
    SMILES

    OC[C@@H]1[C@H](C[C@H](N2C(NC(C(I)=C2)=O)=O)O1)O.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Idoxuridine hydrate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Idoxuridine17140-71-55-Iodo-2′-deoxyuridine5-IUdRIdUrdDNA/RNA SynthesisPhosphataseAntiviral agentsPhosphorylases inhibitorDNA polymeraseHerpesvirusesFeline herpesvirusIodinated thymidine analogueInhibitorinhibitorinhibit

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