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Art. -Nr.: HY-169002

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PP5-IN-2

PP5-IN-2 is an orally active and selective protein phosphatase 5 (PP5) inhibitor with an IC₅₀ value of 0.9 μM. PP5-IN-2 activates p53 and downregulates cyclin D1 and MGMT, which shows potency in cell cycle arrest and reverses Temozolomide (TMZ) (HY-17364) resistance in the U87 MG cell line. PP5-IN-2 effectively inhibits tumor growth in the xenograft mouse model.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₆H₁₅NO₄
Molecular Weight:285.29

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PP5-IN-2 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	69.6 μM Compound: 28a	Cytotoxicity against human A549 cells incubated for 48 hrs by CCK8 assay Cytotoxicity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 39136241]
BEAS-2B	IC₅₀	57.8 μM Compound: 28a	Cytotoxicity against human BEAS-2B incubated for 48 hrs by CCK8 assay Cytotoxicity against human BEAS-2B incubated for 48 hrs by CCK8 assay	[PMID: 39136241]
HCT-116	IC₅₀	26.5 μM Compound: 28a	Cytotoxicity against human HCT-116 cells incubated for 48 hrs by CCK8 assay Cytotoxicity against human HCT-116 cells incubated for 48 hrs by CCK8 assay	[PMID: 39136241]
HEK-293T	IC₅₀	>200 μM Compound: 28a	Cytotoxicity against HEK293T cells incubated for 48 hrs by CCK8 assay Cytotoxicity against HEK293T cells incubated for 48 hrs by CCK8 assay	[PMID: 39136241]
HUVEC	IC₅₀	>200 μM Compound: 28a	Cytotoxicity against HUVECs incubated for 48 hrs by CCK8 assay Cytotoxicity against HUVECs incubated for 48 hrs by CCK8 assay	[PMID: 39136241]
U-87MG ATCC	IC₅₀	19.8 μM Compound: 28a	Synergistic antiproliferative activity against human U-87 MG cells in presence of TMZ Synergistic antiproliferative activity against human U-87 MG cells in presence of TMZ	[PMID: 39136241]
U-87MG ATCC	IC₅₀	70.1 μM Compound: 28a	Cytotoxicity against human U-87 MG cells incubated for 48 hrs by CCK8 assay Cytotoxicity against human U-87 MG cells incubated for 48 hrs by CCK8 assay	[PMID: 39136241]

Chemical Information

Molecular Weight 285.29
Formel C₁₆H₁₅NO₄
SMILES

O=C([C@H]1[C@](O2)([H])CC[C@]2([H])[C@H]1C(N3C=CC4=C3C=CC=C4)=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li Z, et al. Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme. J Med Chem. 2024 Sep 12;67(17):15691-15710. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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