2. Signaling Pathways
  3. GPCR/G Protein
    MAPK/ERK Pathway
  4. Ras

Ras

Ras

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168847
    INCB159020
    		Inhibitor
    INCB159020 is an orally active KRAS G12D inhibitor with a KRAS G12D SPR value of 2.2 nM. INCB159020 has antitumor activity.
    INCB159020
  • HY-131598
    6-Thio-GTP
    		Inhibitor
    6-Thio-GTP is an analogue of GTP, and a metabolite of an immunosuppressive drug, Azathioprine (HY-B0256).
    6-Thio-GTP
  • HY-144657A
    (4S)-PROTAC SOS1 degrader-1 diTFA
    		Inhibitor 98.09%
    (4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo.
    (4S)-PROTAC SOS1 degrader-1 diTFA
  • HY-178194
    SHY-855
    		Inhibitor
    SHY-855 is a pan RAS inhibitor. SHY-855 effectively prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases with IC50 values of 0.3-5 μM. SHY-855 effectively inhibits the phosphorylation of MEK, ERK1/2, and AKT downstream of K-Ras. SHY-855 inhibits the formation of the Ras-GTP activity complex. SHY-855 can be used to the studies of pancreatic cancer and non-small cell lung cancer.
    SHY-855
  • HY-P10051
    Cyclorasin 9A5
    		Inhibitor
    Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM.
    Cyclorasin 9A5
  • HY-P10650
    FAM49B (190-198) mouse
    		Inhibitor 99.76%
    FAM49B (190-198) mouse is a peptide fragment of FAM49B. FAM49B is a mitochondria-localized protein that regulates mitochondrial fission. FAM49B regulates mitochondrial function and integrity and tumor progression. FAM49B is also a negative regulator in T cell activation, it acts by repressing GTPase Rac activity and modulating cytoskeleton reorganization.
    FAM49B (190-198) mouse
  • HY-186001
    RMC-9945
    		Inhibitor
    RMC-9945 (RM-044) is a KRAS inhibitor and selective, covalent, orally active RAS(ON) G12D inhibitor. RMC-9945 increases β-Catenin/TCF transcriptional activity. RMC-9945 exerts durable disease control in preclinical colorectal cancer models of early liver metastasis.
    RMC-9945
  • HY-178837
    Z56
    		Inhibitor
    Z56 is a Ras protein inhibitor. Z56 can be used for the research of cancer, such as pancreatic cancer.
    Z56
  • HY-W747572
    (+)-Perillyl alcohol
    		Inhibitor
    (+)-Perillyl alcohol is the enantiomer of S-(-)-Perillyl alcohol (HY-116514). (+)-Perillyl alcohol can inhibit the growth of polypeptides and block the cell cycle in the G0/G1 phase. (+)-Perillyl alcohol induces cell signaling that is associated with changes in cytoskeletal actin organization and reduced protein expression of growth regulatory proteins such as Ras and CDC2 kinase.
    (+)-Perillyl alcohol
  • HY-118692
    DCAI
    		Inhibitor
    DCAI is Ras protein binder. DCAI can inhibit the Ras activation and nucleotide exchange mediated by SOS. DCAI can be used for the research of cancer associated with Ras mutations .
    DCAI
  • HY-161767
    JWJ-01-306
    JWJ-01-306 is a CRBN-recruiting ZBTB11 Molecular Glues degrader. JWJ-01-306 degrades ZBTB11 and reprograms cellular metabolism, thereby reducing the level of Oxidative Phosphorylation and the activity of the tricarboxylic acid cycle. JWJ-01-306 enhances the response of organoids to K-Ras inhibition. JWJ-01-306 inhibits the proliferation of pancreatic ductal adenocarcinoma cells and melanoma cells. JWJ-01-306 can be used in studies related to pancreatic ductal adenocarcinoma and melanoma.
    JWJ-01-306
  • HY-139612A
    (S)-Opnurasib
    		Inhibitor 99.32%
    (S)-Opnurasib ((S)-JDQ-443; (S)-NVP-JDQ443) is an isomer of Opnurasib (HY-139612). Opnurasib is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity.
    (S)-Opnurasib
  • HY-170327
    ZCL279
    		Inhibitor 99.20%
    ZCL279 is a small molecule modulator (SMM) that inhibits Cdc42-intersectin (ITSN) interaction. ZCL279 can activate Cdc42 (a cytoplasmic small GTPase in the Ras superfamily) at lower concentrations (<10 μM) and significantly inhibit it at higher concentrations (<10 μM).
    ZCL279
  • HY-180801
    E8431
    		Inhibitor
    E8431 is a DCSTAMP antagonist. DCSTAMP is a key fusion protein that coordinates cell-cell fusion during osteoclastogenesis. E8431 inhibits the cytoskeleton reorganization mediated by the RAP1B-RAC1 signaling pathway. E8431 has the ability to inhibit pre-fusion of osteoclasts and, while inhibiting bone resorption, stimulates the secretion of PDGFBB, thereby stimulating the process of bone and blood vessel formation. E8431 effectively reduces bone loss in a mouse model caused by ovariectomy. E8431 can be used for the study of osteoporosis.
    E8431
  • HY-164749
    K-Ras-IN-4
    		Inhibitor
    K-Ras-IN-4 (compund CP163) is a K-Ras inhibitor.
    K-Ras-IN-4
  • HY-P3277A
    KRpep-2d TFA
    		Inhibitor 98.11%
    KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.
    KRpep-2d TFA
  • HY-P2361
    S12
    		99.70%
    S12 is a mutant RAS peptide containing the Gly (G) to Ser (S12) substitution. The sequence of the peptide is KLVVVGASGVGKS.
    S12
  • HY-143603
    KRAS G12D inhibitor 10
    		Inhibitor
    KRAS G12D inhibitor 10 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 10 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 34).
    KRAS G12D inhibitor 10
  • HY-114398A
    (S)-BAY-293
    		Control
    (S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor.
    (S)-BAY-293
  • HY-B0105R
    Ketoconazole (Standard)
    		Inhibitor
    Ketoconazole (Standard) is the analytical standard of Ketoconazole. This product is intended for research and analytical applications. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Ras Isoform Comparison

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