2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. ZCL279

ZCL279 is a small molecule modulator (SMM) that inhibits Cdc42-intersectin (ITSN) interaction. ZCL279 can activate Cdc42 (a cytoplasmic small GTPase in the Ras superfamily) at lower concentrations (<10 μM) and significantly inhibit it at higher concentrations (<10 μM).

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ZCL279

ZCL279 Chemical Structure

CAS No. : 664975-73-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

ZCL279 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ZCL279

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Description

ZCL279 is a small molecule modulator (SMM) that inhibits Cdc42-intersectin (ITSN) interaction. ZCL279 can activate Cdc42 (a cytoplasmic small GTPase in the Ras superfamily) at lower concentrations (<10 μM) and significantly inhibit it at higher concentrations (<10 μM)[1].

Molecular Weight

510.54

Formula

C24H18N2O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC=C1NS(=O)(C2=CC=C(OC3=C4C=C(S(=O)(NC5=C(O)C=CC=C5)=O)C=C3)C4=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (97.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9587 mL 9.7936 mL 19.5871 mL
5 mM 0.3917 mL 1.9587 mL 3.9174 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9587 mL 9.7936 mL 19.5871 mL 48.9678 mL
5 mM 0.3917 mL 1.9587 mL 3.9174 mL 9.7936 mL
10 mM 0.1959 mL 0.9794 mL 1.9587 mL 4.8968 mL
15 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2645 mL
20 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4484 mL
25 mM 0.0783 mL 0.3917 mL 0.7835 mL 1.9587 mL
30 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
40 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL
50 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.9794 mL
60 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8161 mL
80 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6121 mL
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ZCL279 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZCL279664975-73-9ZCL 279ZCL-279RasInhibitorinhibitorinhibit

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