1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. Sirtuin
  4. Sirtuin Inhibitors

Sirtuin Inhibitors

Sirtuin

SIRT1

SIRT2

SIRT3

SIRT6

SIRT5

SIRT7

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Sirtuin Inhibitors, Activators & Modulators
Product Name Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 Purity
Selisistat  
SIRT1, IC50: 98 nM
SIRT2, IC50: 19.6 μM
SIRT3, IC50: 48.7 μM
      99.87%
Nicotinamide riboside chloride  
SIRT1
 
SIRT3
      99.53%
3-TYP  
SIRT1, IC50: 88 nM
SIRT2, IC50: 92 nM
SIRT3, IC50: 16 nM
      99.76%
CHIC35  
SIRT1, IC50: 0.124 μM
SIRT2, IC50: 2.8 μM
SIRT3, IC50: >100 μM
     
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol  
SIRT1
         
Suramin sodium salt  
SIRT1, IC50: 297 nM
SIRT2, IC50: 1.15 μM
   
SIRT5, IC50: 22 μM
  ≥98.0%
SRT 1720 Hydrochloride  
SIRT1, EC1.5: 0.16 μM
SIRT1, EC50: 0.10 μM
SIRT2, EC1.5: 37 μM
        99.92%
OSS_128167  
SIRT1, IC50: 1578 μM
SIRT2, IC50: 751 μM
 
SIRT6, IC50: 89 μM
    98.06%
SRT 2104  
SIRT1
          ≥98.0%
UBCS039        
SIRT6, EC50: 38 μM
    98.13%
Sirtinol  
ySir2, IC50: 48 μM
hSIRT1, IC50: 131 μM
hSIRT2, IC50: 57.7 μM
        ≥98.0%
CAY10602  
SIRT1
          98.65%
AGK2  
SIRT1, IC50: 30 μM
SIRT2, IC50: 3.5 μM
SIRT3, IC50: 91 μM
      99.62%
Thiomyristoyl  
SIRT1, IC50: 98 μM
SIRT2, IC50: 28 nM
        98.94%
SRT 1720  
SIRT1, EC1.5: 0.16 μM
SIRT2, EC1.5: 37 μM
        99.82%
AK-1    
SIRT2, IC50: 12.5 μM
        99.81%
SIRT7 inhibitor 97491            
SIRT7, IC50: 325 nM
98.05%
Tenovin-6  
SIRT1, IC50: 21 μM
SIRT2, IC50: 10 μM
SIRT3, IC50: 67 μM
      98.61%
AK-7    
SIRT2, IC50: 15.5 μM
        ≥98.0%
Cambinol  
SIRT1, IC50: 56 μM
SIRT2, IC50: 59 μM
        99.70%
Tenovin-1
Sirtuin
            99.88%
PROTAC Sirt2 Degrader-1    
SIRT2, IC50: 0.25 μM
        98.76%
Salermide  
SIRT1
SIRT2
        ≥98.0%
Ganoderic acid D      
SIRT3
      99.40%
SRT 2183  
SIRT1, EC1.5: 0.36 μM
          98.48%
Dihydrocoumarin  
hSIRT1, IC50: 208 μM
hSIRT2, IC50: 295 μM
        99.81%
Inauhzin  
SIRT1
          99.49%
Gardenia yellow      
SIRT3
     
SRT 1460  
SIRT1, EC1.5: 2.9 μM
          98.92%
Agrimol B  
SIRT1
          99.72%
SIRT1-IN-1  
SIRT1, IC50: 0.205 μM
SIRT2, IC50: 11.5 μM
SIRT3, IC50: >100 μM
      98.01%
Sirtuin modulator 1  
SIRT1, EC1.5: 1 μM
          99.44%
Selisistat S-enantiomer  
SIRT1, IC50: 123 nM
          98.50%
Scopolin  
SIRT1
          ≥99.0%
Ophiopogonin D'  
SIRT1
          99.85%
Suramin  
SIRT1, IC50: 297 nM
SIRT2, IC50: 1.15 μM
   
SIRT5, IC50: 22 μM
 
Sirt2-IN-1    
SIRT2, IC50: 163 nM
        98.03%
SirReal2    
SIRT2, IC50: 140 nM
        ≥99.0%
Tenovin-6 Hydrochloride  
SIRT1, IC50: 21 μM
SIRT2, IC50: 10 μM
SIRT3, IC50: 67 μM
      ≥98.0%
SIRT-IN-1  
SIRT1, IC50: 15 nM
SIRT2, IC50: 10 nM
SIRT3, IC50: 33 nM
     
Nicotinamide riboside tartrate  
SIRT1
 
SIRT3
     
Nicotinamide riboside malate  
SIRT1
 
SIRT3
     
SIRT-IN-2  
SIRT1, IC50: 4 nM
SIRT2, IC50: 1 nM
SIRT3, IC50: 7 nM
     
Nicotinamide riboside  
SIRT1
 
SIRT3