1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR Inhibitors

VEGFR Inhibitors

VEGFR1/Flt-1

VEGFR2/KDR/Flk-1

VEGFR3/Flt-4

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

VEGFR Inhibitors & Antagonists
Product Name VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4 Purity
Sorafenib  
VEGFR2, IC50: 90 nM
VEGFR3, IC50: 20 nM
99.92%
Nintedanib
VEGFR1, IC50: 34 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 13 nM
99.97%
Lenvatinib
VEGFR1, IC50: 22 nM
VEGFR2, IC50: 4 nM
VEGFR3, IC50: 5.2 nM
99.74%
Cabozantinib
Flt-1, IC50: 12 nM
VEGFR2, IC50: 0.035 nM
Flt-4, IC50: 6 nM
99.92%
Regorafenib
VEGFR1, IC50: 13 nM
VEGFR2, IC50: 4.2 nM
VEGFR3, IC50: 46 nM
99.96%
Ilorasertib hydrochloride
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 2 nM
VEGFR3, IC50: 43 nM
Semaxinib  
Flk-1, IC50: 1.23 μM
  99.96%
Sunitinib  
VEGFR2, IC50: 80 nM
  99.66%
Sorafenib Tosylate  
VEGFR2, IC50: 90 nM
VEGFR3, IC50: 20 nM
99.53%
Apatinib  
VEGFR2, IC50: 1 nM
  99.93%
Axitinib
VEGFR1, IC50: 0.1 nM
VEGFR2, IC50: 0.2 nM
VEGFR3, IC50: 0.1 nM
99.94%
SU 5402  
VEGFR2, IC50: 20 nM
  99.39%
PD173074  
VEGFR2, IC50: 100 nM
  99.55%
RAF265  
VEGFR2
  99.98%
Sunitinib Malate  
VEGFR2, IC50: 80 nM
  99.47%
Cediranib
Flt-1, IC50: 5 nM
KDR, IC50: 1 nM
Flt-4, IC50: 3 nM
99.58%
Cabozantinib S-malate  
VEGFR2, IC50: 0.035 nM
  99.93%
Linifanib
Flt-1, IC50: 3 nM
KDR, IC50: 4 nM
  99.60%
Nintedanib esylate
VEGFR1, IC50: 34 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 13 nM
99.95%
Sitravatinib
VEGFR1, IC50: 6 nM
VEGFR2, IC50: 5 nM
VEGFR3, IC50: 2 nM
99.85%
Lucitanib
VEGFR1, IC50: 7 nM
VEGFR2, IC50: 25 nM
VEGFR3, IC50: 10 nM
98.24%
Tivozanib
VEGFR1, IC50: 30 nM
VEGFR2, IC50: 6.5 nM
VEGFR3, IC50: 15 nM
99.52%
Gandotinib  
KDR, IC50: 109 nM
Flt-4, IC50: 25 nM
99.96%
5Z-7-Oxozeaenol  
VEGFR-2, IC50: 52 nM
VEGFR-3, IC50: 110 nM
>99.0%
Dovitinib
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 13 nM
VEGFR3, IC50: 8 nM
97.18%
Vatalanib dihydrochloride  
VEGFR2, IC50: 37 nM
  99.86%
SU14813
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 50 nM
  95.74%
PF-03814735
Flt-1, IC50: 10 nM
    99.77%
Brivanib  
VEGFR2, IC50: 25 nM
  99.37%
Altiratinib  
VEGFR2, IC50: 9.2 nM
  95.95%
Regorafenib Hydrochloride
VEGFR1, IC50: 13 nM
VEGFR2, IC50: 4.2 nM
VEGFR3, IC50: 46 nM
99.58%
Pazopanib Hydrochloride
VEGFR1, IC50: 10 nM
VEGFR2, IC50: 30 nM
VEGFR3, IC50: 47 nM
99.83%
PP121  
VEGFR2, IC50: 12 nM
  98.89%
SAR131675    
VEGFR3, IC50: 23 nM
99.80%
Motesanib
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 3 nM
VEGFR3, IC50: 6 nM
99.75%
Golvatinib  
VEGFR2, IC50: 16 nM
  99.29%
Telatinib  
VEGFR2, IC50: 6 nM
VEGFR3, IC50: 4 nM
99.49%
TAK-593
VEGFR1, IC50: 3.2 nM
VEGFR2, IC50: 0.95 nM
VEGFR3, IC50: 1.1 nM
99.62%
Ki8751  
VEGFR2, IC50: 0.9 nM
  98.97%
Regorafenib monohydrate
VEGFR1, IC50: 13 nM
VEGFR2, IC50: 4.2 nM
VEGFR3, IC50: 46 nM
99.96%
Ningetinib  
VEGFR2, IC50: 1.9 nM
  98.75%
Tesevatinib  
KDR, IC50: 1.5 nM
Flt-4, IC50: 8.7 nM
99.21%
ZM323881 hydrochloride  
VEGFR2, IC50: 2 nM
  99.52%
Fruquintinib
VEGFR1, IC50: 33 nM
VEGFR2, IC50: 35 nM
VEGFR3, IC50: 0.5 nM
99.93%
Toceranib phosphate  
Flk-1, Ki: 6 nM
  98.43%
SU1498  
Flk-1, IC50: 700 nM
  99.46%
Toceranib  
Flk-1, Ki: 6 nM
  96.50%
Orantinib
Flt-1, Ki: 2.1 μM
    98.80%
Sulfatinib
VEGFR1
VEGFR2
VEGFR3
97.97%
SU5408  
VEGFR2, IC50: 70 nM
  >98.0%
Cediranib maleate
Flt-1, IC50: 5 nM
KDR, IC50: 1 nM
Flt-4, IC50: 3 nM
96.67%
SU14813 maleate
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 50 nM
  99.34%
Motesanib Diphosphate
VEGFR1, IC50: 2 nM
VEGFR2, IC50: 3 nM
VEGFR3, IC50: 6 nM
99.64%
CGP60474  
VEGFR-2, IC50: 84 nM
  99.88%
CP-547632  
VEGFR-2, IC50: 11 nM
  >99.0%
JI-101  
VEGFR2
  99.95%
ACTB-1003  
VEGFR2, IC50: 2 nM
  97.65%
Chloropyramine hydrochloride    
VEGFR-3
99.30%
SKLB1002  
VEGFR2, IC50: 32 nM
  98.04%
ZM 306416
Flt-1, IC50: 2 μM
KDR, IC50: 100 nM
  99.80%
Brivanib alaninate  
VEGFR2, IC50: 25 nM
  99.76%
AZD2932  
VEGFR2, IC50: 8 nM
  98.12%
BFH772  
VEGFR2, IC50: 3 nM
  96.38%
Acrizanib  
VEGFR-2, IC50: 17.4 nM
  99.84%
SCR-1481B1
VEGFR1
    99.99%
NVP-ACC789
VEGFR-1, IC50: 0.38 μM
VEGFR-2, IC50: 0.02 μM
mVEGFR-2, IC50: 0.23 μM
VEGFR-3, IC50: 0.18 μM
99.58%
Ramucirumab  
VEGFR-2
 
NVP-BAW2881
VEGFR1, IC50: 820 nM
VEGFR2, IC50: 9 nM
VEGFR3, IC50: 420 nM
98.42%
KRN-633
VEGFR1, IC50: 170 nM
VEGFR2, IC50: 160 nM
VEGFR3, IC50: 125 nM
99.06%
CP-547632 hydrochloride  
VEGFR-2, IC50: 11 nM
 
Ningetinib Tosylate  
VEGFR2, IC50: 1.9 nM
  99.88%
BMS-794833  
VEGFR2, IC50: 15 nM
  99.82%
Vandetanib hydrochloride  
VEGFR2, IC50: 40 nM
 
WHI-P180  
KDR, IC50: 66 nM
  99.76%
ZD-4190  
VEGFR2
  99.20%
Ilorasertib
VEGFR1, IC50: 1 nM
VEGFR2, IC50: 2 nM
VEGFR3, IC50: 43 nM
Tyrosine kinase-IN-1
Flt-1, IC50: 4 nM
KDR, IC50: 20 nM
  99.47%
MGCD-265 analog  
VEGFR2, IC50: 10 nM
  96.53%
Lenvatinib mesylate
VEGFR1, IC50: 22 nM
VEGFR2, IC50: 4 nM
VEGFR3, IC50: 5.2 nM
ODM-203
VEGFR1, IC50: 26 nM
VEGFR2, IC50: 9 nM
VEGFR3, IC50: 5 nM
R916562  
VEGF-R2, IC50: 24 nM
 
Vatalanib free base  
VEGFR2, IC50: 37 nM
 
(Z)-Guggulsterone  
VEGF-R2
 
WHI-P180 hydrochloride  
KDR, IC50: 66 nM
 
ZM323881  
VEGFR2, IC50: 2 nM
 
SKLB610
VEGFR1
    98.96%
ZK-261991  
VEGFR2, IC50: 5 nM
 
TAS-115  
VEGFR2, IC50: 30 nM
 
Vandetanib trifluoroacetate  
VEGFR2, IC50: 40 nM
 
KDR-in-4  
KDR, IC50: 7 nM