2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3806):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113468A
    3-O-Methyldopa
    		99.55%
    3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease.
    3-O-Methyldopa
  • HY-Y0075
    2-Naphthaldehyde
    		99.80%
    2-Naphthaldehyde is an aromatic aldehyde. 2-Naphthaldehyde is soluble in various organic solvents. 2-Naphthaldehyde can participate in chemical reactions to generate functionalized ketone derivatives.
    2-Naphthaldehyde
  • HY-W007599
    (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid
    		99.86%
    (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates.
    (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid
  • HY-127112
    Oleic acid alkyne
    		99.96%
    Oleic acid alkyne is Oleic acid (HY-N1446) with an acetylene group. The terminal alkyne group can be used for click chemical ligation reactions. Oleic acid can be hydroxylated by a microsomal cytochrome P-450-dependent system (ω-OAH). Through click chemistry reactions, fluorescent or biotin-labeled oleic acid can be introduced to analyze its metabolism and biological activity.
    Oleic acid alkyne
  • HY-160903
    Suzetrigine phenol
    		99.39%
    Suzetrigine phenol is the phenolate form of the sodium channel modulator Suzetrigine (HY-148800).
    Suzetrigine phenol
  • HY-141572
    1,2-Dioleoyl-sn-glycerol
    		99.96%
    1,2-Dioleoyl-sn-glycerol (sn-1,2-Dioleoylglycerol; 18:1/18:1-DG) is a glycerolipid located on the plasma membrane. 1,2-Dioleoyl-sn-glycerol consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. 1,2-Dioleoyl-sn-glycerol can induce acrosome reaction in human sperm .
    1,2-Dioleoyl-sn-glycerol
  • HY-N10455
    24-Epicastasterone
    		99.91%
    24-Epicastasterone (24-epi-Castasterone) is a bioactive brassinosteroid and a ligand of ABCB1 and ABCB19 in Arabidopsis thaliana. 24-Epicastasterone stimulates the ATPase activity of ABCB19 and the ATP hydrolysis activity of ABCB1, which drive the efflux of substances from plant cells. 24-Epicastasterone increases the activities of catalase and guaiacol peroxidase in the roots of wheat seedlings. 24-Epicastasterone alleviates heat-induced lipid peroxidation through a ROS-dependent mechanism and enhances the heat tolerance of common wheat seedlings.
    24-Epicastasterone
  • HY-13250
    Silvestrol aglycone
    		99.95%
    Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity.
    Silvestrol aglycone
  • HY-143220
    SS(no Galnac)-Inclisiran sodium
    		98.05%
    SS (no Galnac)-Inclisiran sodium is the sense strand of Inclisiran (HY-132591) without GalNAc modification. Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. SS (no Galnac)-Inclisiran sodium can be used in cardiovascular disease research.
    SS(no Galnac)-Inclisiran sodium
  • HY-112349
    SB 203580 sulfone
    		99.25%
    SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases.
    SB 203580 sulfone
  • HY-160410
    Ceramide 3B
    		99.62%
    Ceramide 3B is a ceramide 3 lipid class with aggregation behavior. Ceramide 3B has a variety of physiological functions and can serve as a penetration enhancer and auxiliary emulsifier, playing an important role in barrier function stability.
    Ceramide 3B
  • HY-W015650
    Indole-2-carbaldehyde
    		99.90%
    Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production.
    Indole-2-carbaldehyde
  • HY-17442
    Azathramycin
    		99.85%
    Azathramycin (Azaerythromycin A) is a methylated derivative of the antibiotic Azithromycin (HY-17506).
    Azathramycin
  • HY-172664A
    Trabectedin derivative 2 TFA
    		99.78%
    Trabectedin derivative 2 TFA (compound PL-12) is a Trabectedin derivative that can be used for the study of cancer.
    Trabectedin derivative 2 TFA
  • HY-132248
    C5 Lenalidomide
    		99.62%
    C5 Lenalidomide is a 5-amino-substituted Thalidomide (HY-14658) analog. C5 Lenalidomide inhibits LPS (HY-D1056)-stimulated TNF-α production.
    C5 Lenalidomide
  • HY-P1801A
    Cys-TAT(47-57) TFA
    		98.33%
    Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) TFA, TAT (HY-P0281) derivative, is a Cysteine (HY-Y0337)-tagged cell-penetrating peptide (CPP) derived from the HIV TAT protein. Cys-TAT(47-57) TFA can be used for the research for the research of drug delivery.
    Cys-TAT(47-57) TFA
  • HY-13720A
    Pergolide mesylate
    		99.98%
    Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research.
    Pergolide mesylate
  • HY-113098
    2-Oxovaleric acid
    2-Oxovaleric acid is an analog of Pyruvate and a substrate inhibitor of Lactate dehydrogenase, exhibiting substrate inhibitory activity against lactate dehydrogenase from Phycomyces blakesleeanus.
    2-Oxovaleric acid
  • HY-B0079
    Sugammadex sodium
    		98.0%
    Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex sodium shows nephroprotective effect in ischemia-reperfusion injury.
    Sugammadex sodium
  • HY-N6821
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
    		99.81%
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid is an orally active glucoside derivative of ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be hydrolyzed by α-glucosidase to release ascorbic acid. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid inhibits melanin synthesis, prevents UV-induced cell damage, and promotes collagen synthesis in skin fibroblasts. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid also induces oxidative stress to inhibit tumor growth. 2-O-α-D-Glucopyranosyl-L-ascorbic Acid can be used in research related to tumors, inflammation, and other conditions.
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid