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Sugammadex sodium (Synonyms: Org25969)

Cat. No.: HY-B0079 Purity: >98.0%
Handling Instructions

Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.

For research use only. We do not sell to patients.
Sugammadex sodium Chemical Structure

Sugammadex sodium Chemical Structure

CAS No. : 343306-79-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 144 In-stock
10 mg USD 60 In-stock
50 mg USD 132 In-stock
100 mg USD 180 In-stock
200 mg USD 288 In-stock
500 mg USD 540 In-stock
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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.

In Vivo

Injection of sugammadex has no significant effects on blood pressure or heart rate. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio takes 28 min (SD 7 min) after saline, 26 min (SD 9.5 min) after 1 mg/kg sugammadex, and 8 min (SD 3.6 min) after 2.5 mg/kg sugammadex[1]. Sugammadex causes a rapid and complete reversal of rocuronium-induced neuromuscular block. The recovery time to train of four ratio=0.9 after spontaneous recovery is 14.4 min (SD=3.4 min; n=14). This is reduced significantly to 3.7 min (SD=3.3 min; n=4) with sugammadex 0.5 mg/kg and to 1.9 min (SD=1.0 min; n=4) with sugammadex 1.0 mg/kg[2]. The estimated half-life of sugammadex in Rhesus monkey is 30 (SEM=4.9) min[3].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.4591 mL 2.2957 mL 4.5913 mL
5 mM 0.0918 mL 0.4591 mL 0.9183 mL
10 mM 0.0459 mL 0.2296 mL 0.4591 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

Sugammadex is formulated in saline.

Female rhesus monkeys with a body weight of 5.2-7.1 kg are sedated with 10 mg/kg ketamine intramuscularly. Two intravenous lines are placed: one for anesthetic administration, including rocuronium, the other for test drug administration. This is followed by intravenous injection of 25 mg/kg pentobarbitone sodium and a subsequent continuous infusion of 5-10 mg/kg/h. The monkeys are intubated endotracheally, and the lungs are ventilated with a mixture of oxygen and nitrous oxide (volume ratio of 2:3). Four animals are each studied on three different occasions. The occasions differed by the administration of either saline or a low (1.0 mg/kg) or high (2.5 mg/kg) dose of sugammadex. Between the experiments, the monkeys recover for at least 6 weeks. Heart rate and oxygen saturation are determined at the ear with a pulse oximeter. Blood pressure is determined with a cuff placed around the tail. Body temperature is measured by a rectal probe and kept at 37°C-38°C. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2178.01

Formula

C₇₂H₁₀₄Na₈O₄₈S₈

CAS No.

343306-79-6

SMILES

[O-]C(CCSC[[email protected]@H]1OC(O[[email protected]@H]2[[email protected]]([[email protected]](O)C(O[[email protected]]3[[email protected]](CSCCC([O-])=O)OC(O[[email protected]]4[[email protected]](CSCCC([O-])=O)OC5[[email protected]@H](O)[[email protected]@H]4O)[[email protected]@H](O)[[email protected]@H]3O)O[[email protected]]2CSCCC([O-])=O)O)[[email protected]@H](O)[[email protected]](O)[[email protected]]1OC(O[[email protected]@H](CSCCC([O-])=O)[[email protected]](OC6[[email protected]@H](O)[[email protected]](O)[[email protected]@H](OC7[[email protected]@H](O)[[email protected]](O)[[email protected]@H](OC8[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O5)[[email protected]](CSCCC([O-])=O)O8)[[email protected]](CSCCC([O-])=O)O7)[[email protected]](CSCCC([O-])=O)O6)[[email protected]]9O)[[email protected]]9O)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Sugammadex sodium
Cat. No.:
HY-B0079
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