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Sugammadex sodium (Synonyms: Org25969)

Cat. No.: HY-B0079 Purity: >98.0%
Handling Instructions

Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.

For research use only. We do not sell to patients.
Sugammadex sodium Chemical Structure

Sugammadex sodium Chemical Structure

CAS No. : 343306-79-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 144 In-stock
10 mg USD 60 In-stock
50 mg USD 132 In-stock
100 mg USD 180 In-stock
200 mg USD 288 In-stock
500 mg USD 540 In-stock
1 g   Get quote  
5 g   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.

In Vivo

Injection of sugammadex has no significant effects on blood pressure or heart rate. After injection of the high rocuronium dose, the 90% recovery of the train-of-four ratio takes 28 min (SD 7 min) after saline, 26 min (SD 9.5 min) after 1 mg/kg sugammadex, and 8 min (SD 3.6 min) after 2.5 mg/kg sugammadex[1]. Sugammadex causes a rapid and complete reversal of rocuronium-induced neuromuscular block. The recovery time to train of four ratio=0.9 after spontaneous recovery is 14.4 min (SD=3.4 min; n=14). This is reduced significantly to 3.7 min (SD=3.3 min; n=4) with sugammadex 0.5 mg/kg and to 1.9 min (SD=1.0 min; n=4) with sugammadex 1.0 mg/kg[2]. The estimated half-life of sugammadex in Rhesus monkey is 30 (SEM=4.9) min[3].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.4591 mL 2.2957 mL 4.5913 mL
5 mM 0.0918 mL 0.4591 mL 0.9183 mL
10 mM 0.0459 mL 0.2296 mL 0.4591 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Sugammadex is formulated in saline.

Female rhesus monkeys with a body weight of 5.2-7.1 kg are sedated with 10 mg/kg ketamine intramuscularly. Two intravenous lines are placed: one for anesthetic administration, including rocuronium, the other for test drug administration. This is followed by intravenous injection of 25 mg/kg pentobarbitone sodium and a subsequent continuous infusion of 5-10 mg/kg/h. The monkeys are intubated endotracheally, and the lungs are ventilated with a mixture of oxygen and nitrous oxide (volume ratio of 2:3). Four animals are each studied on three different occasions. The occasions differed by the administration of either saline or a low (1.0 mg/kg) or high (2.5 mg/kg) dose of sugammadex. Between the experiments, the monkeys recover for at least 6 weeks. Heart rate and oxygen saturation are determined at the ear with a pulse oximeter. Blood pressure is determined with a cuff placed around the tail. Body temperature is measured by a rectal probe and kept at 37°C-38°C. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







[O-]C(CCSC[[email protected]@H]1OC(O[[email protected]@H]2[[email protected]]([[email protected]](O)C(O[[email protected]]3[[email protected]](CSCCC([O-])=O)OC(O[[email protected]]4[[email protected]](CSCCC([O-])=O)OC5[[email protected]@H](O)[[email protected]@H]4O)[[email protected]@H](O)[[email protected]@H]3O)O[[email protected]]2CSCCC([O-])=O)O)[[email protected]@H](O)[[email protected]](O)[[email protected]]1OC(O[[email protected]@H](CSCCC([O-])=O)[[email protected]](OC6[[email protected]@H](O)[[email protected]](O)[[email protected]@H](OC7[[email protected]@H](O)[[email protected]](O)[[email protected]@H](OC8[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O5)[[email protected]](CSCCC([O-])=O)O8)[[email protected]](CSCCC([O-])=O)O7)[[email protected]](CSCCC([O-])=O)O6)[[email protected]]9O)[[email protected]]9O)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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