Glyoxalase (GLO) Inhibitor

BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC₅₀ of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.

N,S-Bis-Fmoc-Glutathione is a potent glyoxalase II inhibitor with a K_i value of 0.75 μM and an IC₅₀ of 2.5 μM.

S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH. S-Methylglutathione has inhibitory effect on glyoxalase 1.

Glyoxalase I inhibitor free base (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research.

TLSC702 is a human glyoxalase I (hGLO I) inhibitor with an IC₅₀ of 2.0 μM. TLSC702 inhibits the activity of human glyoxalase I, thereby leading to the accumulation of methylglyoxal and its derived advanced glycation end products. TLSC702 inhibits tumor cell proliferation, induces apoptotic morphological changes, internucleosomal DNA fragmentation and PARP cleavage in tumor cells. TLSC702 can be used in research related to leukemia and lung cancer.

Enzyme-IN-4 is a competitive inhibitor of glyoxalase I that can be found in Stereum hirsutum. Enzyme-IN-4 has a K_i value of 4.6 μM against rat liver glyoxalase I.

SPB07393SC is a glyoxalase-I (Glo-I) inhibitor with an IC₅₀ of 11.1 μM. SPB07393SC is applicable for cancer research.

N,S-Bis-Fmoc-Glutathione TFA is a potent glyoxalase II inhibitor with a K_i value of 0.75 μM and an IC₅₀ of 2.5 μM.

2-Dimethylaminophenol is an inhibitor of human glyoxalase 1 (GLO1). 2-Dimethylaminophenol disrupts metal binding by substituting the pyridine nitrogen donor with a dimethylamino group.

Glyoxalase I inhibitor (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research.

Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC₅₀ of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity.

Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety.

TS010 is a potent inhibitor of GLO-I with IC₅₀ of 0.57 μM. TS010 has the potential for the research of cancer disease.

Glyoxalase I inhibitor 7 (Compound 6) is a glyoxalase I (Glo-I) inhibitor with an IC₅₀ of 3.65 μM. Glyoxalase I inhibitor 7 can be used as anticancer agent.

COMC-6 is an anticancer agent and can be used for study of cancer.

Glyoxalase I inhibitor 4 (compound 14) is a potent glyoxalase I inhibitor with an K_i of 10 nM.

Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 26 nM. Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety.

COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC₅₀ = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.

Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class.