Glyoxalase I inhibitor 3

Name: Glyoxalase I inhibitor 3
Brand: MedChemExpress
SKU: HY-146655
Rating: 4.5 (0 reviews)

製品番号: HY-146655 純度: 98.06%: Data Sheet SDS COA 取扱説明書
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Technical Support

Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Glyoxalase I inhibitor 3 構造式

CAS 番号 : 1415388-25-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 616	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 616	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$560	在庫あり	Estimated Time of Arrival: December 31
10 mg	$900	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1800	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

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製品説明

IC₅₀ & Target

IC₅₀: 0.011 µM (GLO1)^[1]

分子量

375.42

分子式

C₂₂H₂₁N₃O₃

CAS 番号

1415388-25-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=C(C2=CC=CC=C2)C=C(N1O)C3=CN=C4C(C=CN4CCCOC)=C3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (266.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6637 mL	13.3184 mL	26.6368 mL
5 mM	0.5327 mL	2.6637 mL	5.3274 mL
10 mM	0.2664 mL	1.3318 mL	2.6637 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.06%

Select Batch:

データシート (271 KB) SDS (251 KB)

COA (249 KB) HNMR (238 KB) LCMS (95 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jin T, Zhao L, et al. Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6637 mL	13.3184 mL	26.6368 mL	66.5921 mL
	5 mM	0.5327 mL	2.6637 mL	5.3274 mL	13.3184 mL
	10 mM	0.2664 mL	1.3318 mL	2.6637 mL	6.6592 mL
	15 mM	0.1776 mL	0.8879 mL	1.7758 mL	4.4395 mL
	20 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3296 mL
	25 mM	0.1065 mL	0.5327 mL	1.0655 mL	2.6637 mL
	30 mM	0.0888 mL	0.4439 mL	0.8879 mL	2.2197 mL
	40 mM	0.0666 mL	0.3330 mL	0.6659 mL	1.6648 mL
	50 mM	0.0533 mL	0.2664 mL	0.5327 mL	1.3318 mL
	60 mM	0.0444 mL	0.2220 mL	0.4439 mL	1.1099 mL
	80 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8324 mL
	100 mM	0.0266 mL	0.1332 mL	0.2664 mL	0.6659 mL