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Cat. No.: HY-153154

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COMC-6

(Synonyms: 2-Crotonyloxymethyl-2-cyclohexenone)

COMC-6 is an anticancer agent and can be used for study of cancer.

For research use only. We do not sell to patients.

CAS No.: 106281-45-2
Formula: C₁₁H₁₄O₃
Molecular Weight:194.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

COMC-6 Chemical Structure

CAS No.: 106281-45-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

COMC-6 is an anticancer agent and can be used for study of cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	55 μM Compound: 2, COMC	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 17174551]
A549	IC₅₀	55 μM Compound: 2, COMC	Cytotoxicity against human A549 cells assessed as surviving cells after 4 days by MTT assay Cytotoxicity against human A549 cells assessed as surviving cells after 4 days by MTT assay	[PMID: 17870533]
B16	IC₅₀	0.046 μM Compound: COMC-6	Tested in vitro growth inhibition against B16 melanotic melanoma cells Tested in vitro growth inhibition against B16 melanotic melanoma cells	[PMID: 12502374]
HepG2	IC₅₀	5.93 μM Compound: COMC-6	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 32787089]
HT-29	IC₅₀	0.8 μM Compound: COMC-6	Tested for cytotoxicity against HT-29 (wt)cells Tested for cytotoxicity against HT-29 (wt)cells	[PMID: 12502374]
HT-29	IC₅₀	1.8 μM Compound: COMC-6	Tested for cytotoxicity against HT-29 (MDR)cells Tested for cytotoxicity against HT-29 (MDR)cells	[PMID: 12502374]
HT-29	IC₅₀	4.37 μM Compound: COMC-6	Antiproliferative activity against human HT-29 cells by MTT assay Antiproliferative activity against human HT-29 cells by MTT assay	[PMID: 32787089]
NCI-H460	IC₅₀	40 μM Compound: 2, COMC	Cytotoxicity against human H460 cells by MTT assay Cytotoxicity against human H460 cells by MTT assay	[PMID: 17174551]
NCI-H460	IC₅₀	40 μM Compound: 2, COMC	Cytotoxicity against human H460 cells assessed as surviving cells after 4 days by MTT assay Cytotoxicity against human H460 cells assessed as surviving cells after 4 days by MTT assay	[PMID: 17870533]

In Vitro

COMC-6 (72 h) inhibits the proliferation of B16 murine melanoma cells with the IC₅₀ of 0.041 µM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 106281-45-2
Molecular Weight 194.23
Formula C₁₁H₁₄O₃
SMILES

C/C=C/C(OCC1=CCCCC1=O)=O
Synonyms

2-Crotonyloxymethyl-2-cyclohexenone
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Joseph E, et al. Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. J Med Chem. 2003;46(1):194-196. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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