Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

  • Bioorg Med Chem Lett. 2007 Jan 15;17(2):553-7. doi: 10.1016/j.bmcl.2006.09.072.
Claire L Arthurs  1 ,  Natasha S Wind ,  Roger C Whitehead ,  Ian J Stratford
Affiliations
  • 1. School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
PMID: 17174551 DOI: 10.1016/j.bmcl.2006.09.072
Abstract

The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung Cancer cell lines are presented.