Arene cis-dihydrodiols: useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

  • Bioorg Med Chem Lett. 2007 Nov 1;17(21):5974-7. doi: 10.1016/j.bmcl.2007.07.070.
Claire L Arthurs  1 ,  James Raftery ,  Helen L Whitby ,  Roger C Whitehead ,  Natasha S Wind ,  Ian J Stratford
Affiliations
  • 1. School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
PMID: 17870533 DOI: 10.1016/j.bmcl.2007.07.070
Abstract

The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented.

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