S-Methylglutathione

Name: S-Methylglutathione
Brand: MedChemExpress
SKU: HY-W009177
Rating: 4.5 (1 reviews)

Cat. No.: HY-W009177 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH. S-Methylglutathione has inhibitory effect on glyoxalase 1.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

S-Methylglutathione Chemical Structure

CAS No. : 2922-56-7

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH^[1]. S-Methylglutathione has inhibitory effect on glyoxalase 1^[2].

In Vitro

S-Methylglutathione (GS-Me) is a stronger nucleophile than GSH, which is rationalized by the more positive inductive effect of the methyl group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

321.35

Formula

C₁₁H₁₉N₃O₆S

CAS No.

2922-56-7

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (77.80 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1119 mL	15.5594 mL	31.1187 mL
5 mM	0.6224 mL	3.1119 mL	6.2237 mL
10 mM	0.3112 mL	1.5559 mL	3.1119 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (244 KB) HNMR (300 KB) LCMS (263 KB)

Handling Instructions (2659 KB)

References

[1]. Foye WO, et al. Synthesis and evaluation of N-alkanoyl-S-benzyl-L-cysteinylglutamic acid esters as glyoxalase I inhibitors and anticancer agents. J Pharm Sci. 1984 Apr;73(4):559-61. [Content Brief]

[2]. Milos I. Djuran,et al. Reactivity of chloro- and aqua(diethylenetriamine)platinum(II) ions with glutathione, S-methylglutathione, and guanosine 5'-monophosphate in relation to the antitumor activity and toxicity of platinum complexes. Inorg. Chem. 1991, 30, 12, 2648–2652

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.1119 mL	15.5594 mL	31.1187 mL	77.7968 mL
	5 mM	0.6224 mL	3.1119 mL	6.2237 mL	15.5594 mL
	10 mM	0.3112 mL	1.5559 mL	3.1119 mL	7.7797 mL
	15 mM	0.2075 mL	1.0373 mL	2.0746 mL	5.1865 mL
	20 mM	0.1556 mL	0.7780 mL	1.5559 mL	3.8898 mL
	25 mM	0.1245 mL	0.6224 mL	1.2447 mL	3.1119 mL
	30 mM	0.1037 mL	0.5186 mL	1.0373 mL	2.5932 mL
	40 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9449 mL
	50 mM	0.0622 mL	0.3112 mL	0.6224 mL	1.5559 mL
	60 mM	0.0519 mL	0.2593 mL	0.5186 mL	1.2966 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.