country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-146653

Copy Link Print Information

Glyoxalase I inhibitor 1

Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 26 nM. Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 1622952-07-1
Formula: C₃₀H₂₇FN₆O₄S
Molecular Weight:586.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Glyoxalase I inhibitor 1 Chemical Structure

CAS No.: 1622952-07-1

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC₅₀ of 26 nM^[1]. Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

IC₅₀: 26 nM µM (GLO1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	13.3 μM Compound: L1-Bpyne	Growth inhibition of human A549 cells after 48 hrs by CellTiter-Glo assay in presence of 25 mM glucose Growth inhibition of human A549 cells after 48 hrs by CellTiter-Glo assay in presence of 25 mM glucose	10.1039/C3MD00286A
A549	GI₅₀	15.5 μM Compound: L1-Bpyne	Growth inhibition of human A549 cells after 48 hrs by CellTiter-Glo assay in presence of 5 mM glucose Growth inhibition of human A549 cells after 48 hrs by CellTiter-Glo assay in presence of 5 mM glucose	10.1039/C3MD00286A
HeLa	GI₅₀	4.6 μM Compound: L1-Bpyne	Growth inhibition of human HeLa cells after 48 hrs by CellTiter-Glo assay in presence of 25 mM glucose Growth inhibition of human HeLa cells after 48 hrs by CellTiter-Glo assay in presence of 25 mM glucose	10.1039/C3MD00286A
HeLa	GI₅₀	5.7 μM Compound: L1-Bpyne	Growth inhibition of human HeLa cells after 48 hrs by CellTiter-Glo assay in presence of 5 mM glucose Growth inhibition of human HeLa cells after 48 hrs by CellTiter-Glo assay in presence of 5 mM glucose	10.1039/C3MD00286A
NCI-H522	GI₅₀	2.7 μM Compound: L1-Bpyne	Growth inhibition of human NCI-H522 cells after 48 hrs by CellTiter-Glo assay in presence of 5 mM glucose Growth inhibition of human NCI-H522 cells after 48 hrs by CellTiter-Glo assay in presence of 5 mM glucose	10.1039/C3MD00286A
NCI-H522	GI₅₀	2.9 μM Compound: L1-Bpyne	Growth inhibition of human NCI-H522 cells after 48 hrs by CellTiter-Glo assay in presence of 25 mM glucose Growth inhibition of human NCI-H522 cells after 48 hrs by CellTiter-Glo assay in presence of 25 mM glucose	10.1039/C3MD00286A

Chemical Information

CAS No. 1622952-07-1
Molecular Weight 586.64
Formula C₃₀H₂₇FN₆O₄S
SMILES

C#CCCCC(NC1=CC=C(C=C1)C(C2=CC=C(C=C2)NC3=NC=C(C(NC4=C(C=CC=C4)NS(C)(=O)=O)=N3)F)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin T, Zhao L, et al. Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote