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BrBzGCp2 (Synonyms: S-p-Bromobenzylglutathione cyclopentyl diester)

Cat. No.: HY-136684 Purity: 98.88%
Handling Instructions

BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.

For research use only. We do not sell to patients.

BrBzGCp2 Chemical Structure

BrBzGCp2 Chemical Structure

CAS No. : 166038-00-2

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10 mM * 1 mL in DMSO USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
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10 mg USD 140 In-stock
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25 mg USD 300 In-stock
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50 mg USD 500 In-stock
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100 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2].

IC50 & Target

GC50: 4.23 μM (GLO1)[1].

In Vivo

GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior[2].
BrBzGCp2 pre-treatment decreases seizure duration[3].
BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels[4].
BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABAA receptor activation[4].
BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice[2].
Dosage: 50 mg/kg.
Administration: IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured)
Result: Allowed MG levels to accumulate for 2 hours
Molecular Weight

612.58

Formula

C₂₇H₃₈BrN₃O₆S

CAS No.

166038-00-2

SMILES

O=C(NCC(OC1CCCC1)=O)[[email protected]@H](NC(CC[[email protected]](N)C(OC2CCCC2)=O)=O)CSCC(C=C3)=CC=C3Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (408.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6324 mL 8.1622 mL 16.3244 mL
5 mM 0.3265 mL 1.6324 mL 3.2649 mL
10 mM 0.1632 mL 0.8162 mL 1.6324 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BrBzGCp2S-p-Bromobenzylglutathione cyclopentyl diesterBrBzGCp 2BrBzGCp-2OthersAutismspectrumdisorderanxietyGABAInhibitorinhibitorinhibit

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Product Name:
BrBzGCp2
Cat. No.:
HY-136684
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