166038-00-2
166038-00-2
Chemical Structure
BrBzGCp2
Synonym(s): S-p-Bromobenzylglutathione cyclopentyl diester
- CAS No.: 166038-00-2
- Formula:C27H38BrN3O6S
- Molecular Weight:612.58
IUPAC Name: cyclopentyl N5-((R)-3-((4-bromobenzyl)thio)-1-((2-(cyclopentyloxy)-2-oxoethyl)amino)-1-oxopropan-2-yl)-L-glutaminate
InChIKey: QIFSPGPRHFNZNN-GOTSBHOMSA-N
SMILES: O=C(NCC(OC1CCCC1)=O)[C@@H](NC(CC[C@H](N)C(OC2CCCC2)=O)=O)CSCC(C=C3)=CC=C3Br
Biological Activity:
BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BrBzGCp2 | 99.00% | BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity. |
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References
- [1]. P J Thornalley, et al. Antitumor activity of S-(p-bromobenzyl)glutathione diesters in vitro: a structure-activity study. J Med Chem. 1996 Aug 16;39(17):3409-11. [Content Brief]
- [2]. Margaret G Distler, et al. Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal. J Clin Invest. 2012 Jun;122(6):2306-15. [Content Brief]
Keywords
