Insecticide

Insecticides refer to any toxic substances used to kill insects, which exert toxic effects on pests through different mechanisms, thereby achieving the purpose of controlling pest populations and protecting crops and human health. Insecticides have both chemical and biological origins and can be classified into organochlorine insecticides, organophosphorus insecticides, carbamate insecticides, and mineral insecticides based on their chemical properties. Insecticides interact with different target and non-target sites, including receptors, enzymes, and many other known and unknown molecules. Most insecticides are neurotoxicants that target the nervous system, but they can also affect other organs and body systems. Insecticides are metabolized through different metabolic pathways and often serve as biomarkers of exposure in the form of their parent compounds or metabolites. The toxicity of insecticides can be acute, subacute, or chronic, depending on the duration of exposure and the dose involved. Therefore, selecting sensitive, accurate, and validated biomarkers of exposure, effects, and susceptibility appears to be a challenging task.
Insecticides are widely used in agriculture, horticulture, forestry, gardening, homes, offices, and other fields^[1]^[2].

References:

[1]. Sparks TC. Insecticide discovery: an evaluation and analysis. Pestic Biochem Physiol. 2013 Sep;107(1):8-17. [Content Brief]

[2]. Gupta R C, et al. Insecticides[M]//Biomarkers in toxicology. Academic Press, 2019: 455-475.

Insecticide Related Products (481):

By Effects:	Inhibitors (27) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N8333

Lepimectin A4
Lepimectin A4, a macrocyclic lactone, is a component of the insecticide Lepimectin.

HY-124920

Methiocarb
Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals.

HY-W338247R

Imidaclothiz (Standard)
Imidaclothiz (Standard) is the analytical standard of Imidaclothiz. This product is intended for research and analytical applications. Imidaclothiz is a kind of neonicotinoid insecticides. Imidaclothiz has excellent insecticidal effect. Imidaclothiz can be used for the research of sucking and biting insects.

HY-B0767

Spinosyn A		99.93%
Spinosyn A, a polyketide-derived macrolide produced by Saccharopolyspora spinosa, is a potent insecticide.

HY-181706

Insecticidal agent 29
Insecticidal agent 29 is a pyrethroid incorporating a pyridine heterocycle and insecticide. Insecticidal agent 29 exhibits insecticidal activity against Culex pipiens Pallens larvae, Aphis laburni Kaltenbach, and aphids. Insecticidal agent 29 shows inactivity against Tetranychus cinnabarinus Boisduval.

HY-157016

OfChi-h-IN-1
OfChi-h-IN-1 is a potent OfChi-h inhibitor with a K_i value of 0.33 μM. OfChi-h-IN-1 dramatically inhibit the growth and development of Ostrinia nubilalis larvae, and it shows higher insecticidal activity than Hexaflumuron (HY-B1848). OfChi-h-IN-1 serves as novel candidates for insect growth regulator.

HY-B1953S

Thiacloprid-d₄
Thiacloprid-d₄ is the deuterium labeled Thiacloprid. Thiacloprid is an orally active neurotoxic insecticide and also a nAChR agonist. Thiacloprid reduces the viability of healthy cells, depletes reduced glutathione, and increases MDA levels, thereby inducing cytotoxicity and oxidative stress damage. In practical applications, Thiacloprid has lower acute toxicity to honeybees than other compounds of the same class such as Imidacloprid (HY-B0838), but it still significantly impairs the learning and memory function, immune capacity and survival status of honeybees. Thiacloprid induces intestinal microbial dysbiosis and reduces survival rate in middle-aged honeybees, increases the risk of premature collapse in bumblebee colonies, and significantly decreases the final colony weight and reproductive output. Thiacloprid is used in broad-spectrum agricultural pest control, often alone or in combination with Deltamethrin (HY-B1971), and meets the pest management needs of various crops including potatoes, cabbages, various fruits and vegetables, and nuts.

HY-W437569

Melicopine
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields.

HY-B0833S

Thiamethoxam-d₄
Thiamethoxam-d₄ is the deuterium labeled Thiamethoxam (HY-B0833). Thiamethoxam is a broad spectrum neonicotinoid insecticide.

HY-124058

Jacobine
Jacobine?is a pyrrolizidine alkaloid (PA) from Senecio jacobaea. Jacobine is active against second instar larvae of thrips.

HY-N15634

Anticopalic acid
Anticopalic acid is a labdane-type diterpenoid insect antifeedant that exhibits dose-dependent antifeedant activity against the fall armyworm (Spodoptera frugiperda). Anticopalic acid can be isolated from Vitex hemsleyi. Anticopalic acid may be involved in neuroreceptor-mediated insect taste regulation and could be used to develop environmentally friendly antifeedants targeting lepidopteran pests.

HY-B0874R

Alpha-Cypermethrin (Standard)
Alpha-Cypermethrin (Standard) is the analytical standard of Alpha-Cypermethrin. This product is intended for research and analytical applications. Alpha-Cypermethrin (FMC 45497; Fendona; WL 85871) is an effective insecticide against house flies.

HY-B1953R

Thiacloprid (Standard)
Thiacloprid (Standard) is the analytical standard of Thiacloprid. This product is intended for research and analytical applications. Thiacloprid is an orally active neurotoxic insecticide and also a nAChR agonist. Thiacloprid reduces the viability of healthy cells, depletes reduced glutathione, and increases MDA levels, thereby inducing cytotoxicity and oxidative stress damage. In practical applications, Thiacloprid has lower acute toxicity to honeybees than other compounds of the same class such as Imidacloprid (HY-B0838), but it still significantly impairs the learning and memory function, immune capacity and survival status of honeybees. Thiacloprid induces intestinal microbial dysbiosis and reduces survival rate in middle-aged honeybees, increases the risk of premature collapse in bumblebee colonies, and significantly decreases the final colony weight and reproductive output. Thiacloprid is used in broad-spectrum agricultural pest control, often alone or in combination with Deltamethrin (HY-B1971), and meets the pest management needs of various crops including potatoes, cabbages, various fruits and vegetables, and nuts.

HY-W747601

Chlorphoxim
Chlorphoxim is a broad-spectrum and highly efficient insecticide. Chlorphoxim kills pests by inhibiting AChE. Chlorphoxim inhibits the activities of SOD and CAT in zebrafish embryos. Chlorphoxim induces oxidative stress in zebrafish embryos by activating ROS. Chlorphoxim induces apoptosis by upregulating the expression levels of Bax, Bcl2 and p53 in zebrafish embryos. Chlorphoxim exhibits neurotoxicity and developmental toxicity. Chlorphoxim is used in agricultural research for the control of various pests.

HY-W727481

Cyetpyrafen
Cyetpyrafen is a pyrazole insecticide/acaricide with broad-spectrum insecticidal activity. Cyetpyrafen binds to DhelOBP4 (K_i = 4.95 μM) and DhelOBP21 (K_i = 5.51 μM) to mediate olfactory recognition in Cryptolaemus montrouzieri. Cyetpyrafen induces dose-dependent electroantennogram responses in Cryptolaemus montrouzieri and exhibits repellent effects on the species. Cyetpyrafen has bioaccumulative properties, is rapidly and passively absorbed by the roots of lettuce and rice, reaches a steady state within 24 h, preferentially accumulates in roots, and shows limited xylem/phloem translocation.

HY-134111

(Z)-9-Dodecenyl acetate
(Z)-9-Dodecenyl acetate is a monounsaturated dodecenyl acetate, an EAG stimulant and an attraction inhibitor. (Z)-9-Dodecenyl acetate is a component of moth sex pheromones. (Z)-9-Dodecenyl acetate elicits electroantennogram (EAG) responses in the antennae of male Choristoneura rosaceana. (Z)-9-Dodecenyl acetate can be used in studies related to pest control.

HY-117901

Sandoricin
Sandoricin is a limonoid compound that can be extracted from the seeds of Sandoricum koetjape. Sandoricin exhibits strong antifeedant properties in larvae of Fall Armyworm (Spodoptera frugiperda) and European Corn Borer (Ostrinia nubilalis) fed on artificial diets. Sandoricin induces reduced growth rate and delayed pupation at lower doses, while higher doses cause massive mortality of larvae. Sandoricin is a potential field insecticide.

HY-W780787

(E,Z)-3,13-Octadecadienyl acetate
(E,Z)-3,13-Octadecadienyl acetate (E3,Z13-18:Ac) is an insect sex pheromone that elicits attraction in male lesser peachtree borers (Lesser Peachtree Borer), which can be isolated from female lesser peachtree borers.

HY-W765182

Emamectin-d₃
Emamectin-d₃ is the deuterium labeled Emamectin. Emamectin is a macrocyclic lactone insecticide. Emamectin acts as agonist for GABA-gated chloride channels.

HY-W587665

Demeton-S sulfoxide
Demeton-S sulfoxide is a systemic insecticide. When Demeton-S sulfoxide is topically applied to cotton stems, it is absorbed and transported to cotton leaves, whereas its penetration and diffusion capabilities are limited when it is topically applied to young lemon leaves.

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