Cyetpyrafen 

Cyetpyrafen is a pyrazole insecticide/acaricide with broad-spectrum insecticidal activity. Cyetpyrafen binds to DhelOBP4 (K_i = 4.95 μM) and DhelOBP21 (K_i = 5.51 μM) to mediate olfactory recognition in *Cryptolaemus montrouzieri*. Cyetpyrafen induces dose-dependent electroantennogram responses in *Cryptolaemus montrouzieri* and exhibits repellent effects on the species. Cyetpyrafen has bioaccumulative properties, is rapidly and passively absorbed by the roots of lettuce and rice, reaches a steady state within 24 h, preferentially accumulates in roots, and shows limited xylem/phloem translocation^[1][2].

Cyetpyrafen (1.12 mg/L; 1-96 h) is rapidly taken up by Oryza sativa (rice) and Lactuca sativa (lettuce) roots, reaching steady state within 24 h, with preferential accumulation in roots (average RCFs 1290 mL/g for rice, 1730 mL/g for lettuce) and poor translocation to shoots, and is eliminated more slowly from lettuce roots than rice roots^[2].
Cyetpyrafen (5 mg/L; 3-96 h) does not undergo phloem-mediated translocation in Oryza sativa seedlings, as it cannot migrate from exposed roots to unexposed roots or shoots^[2].
Cyetpyrafen (1.12 mg/L; 24-96 h) exposure induces significant increases in the activities of CYP450, POD, CarE, GT, and GST in rice and lettuce roots, indicating these enzymes mediate the metabolic transformation of cyetpyrafen in plants^[2].
Cyetpyrafen is predicted to be very toxic to fish and highly toxic to daphnid and green algae, with several of its phase I metabolites (M-391, M-409-1/2, M-407) exhibiting similar ecotoxicity levels, while phase II metabolites show reduced toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyetpyrafen (1-100 mg/L; topical application) elicits a dose-dependent repellent effect and EAG response in adult Dastarcus helophoroides by acting on DhelOBP4 and DhelOBP21, with significant reduction in olfactory sensitivity to all tested concentrations of cyetpyrafen following knockdown of these two odorant binding proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

393.53

C₂₄H₃₁N₃O₂

1253429-01-4

C(=C(\C#N)/C1=CC=C(C(C)(C)C)C=C1)(\OC(C(C)(C)C)=O)/C=2N(CC)N=C(C)C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mao Z, et al. Cyetpyrafen, chlorfenapyr and spirodiclofen affect the olfactory recognition of Dastarcus helophoroides by acting on DhelOBP4 and DhelOBP21. Pestic Biochem Physiol. 2025;214:106568.

  [2]. Li R, et al. Insight into the uptake and metabolism of a new insecticide cyetpyrafen in plants. Environ Int. 2022;169:107522.