2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Kinase

Ser/Thr Kinase

Protein Serine-Threonine Kinase

Ser/Thr Kinase belongs to the eukaryotic protein kinase (ePK) superfamily and can use ATP to phosphorylate the hydroxyl group of serine or threonine residues in the kinase recognition amino acid sequence. The widely known anticancer targets in the Ser/Thr Kinase family are protein kinase C (PKC) and cyclin-dependent kinases (CDKs). There are two types of Ser/Thr Kinase: one is a kinase that phosphorylates receptor molecules, i.e., receptor protein serine/threonine kinases, such as activated receptor kinases and transforming growth factor β receptor kinases; the other is a kinase that acts as an intracellular signal transduction protein. The latter can phosphorylate several key targets of multiple signaling pathways and affect a variety of biological functions including growth, differentiation, cell cycle progression, and metabolism. This family contains several different groups of kinases, including (1) the CK group of kinases: casein kinases; (2) the AGC group: the kinases protein kinase A (PKA), protein kinase B (PKB or v-akt murine thymoma viral oncogene homolog 1: AKT1), and protein kinase C (PKC); (3) the CAMK group of kinases: Ca2+/calmodulin-dependent kinases; (4) the CMGC group of kinases: mos/raf kinases, mitogen-activated kinases (MAPKs), cyclin-dependent kinases (CDKs), and glycogen synthase kinases (GSKs); and (5) the STE group of kinases: homologs of yeast sterile kinases 7, 11, and 20 kinases.Ser/Thr Kinase family regulates the glucocorticoid receptor (GR), a nuclear hormone receptor superfamily protein. For example, MAPK, CDK, PKB/AKT1 and GSK3β can phosphorylate GR at specific residues; PKA, AKT1, PKC, MAPK, AMPK and mTOR can additionally phosphorylate other kinases and/or transcriptional cofactors associated with DNA-associated GR to indirectly regulate GR. It is worth mentioning that p38 MAPK in the MAPK family regulates serine phosphorylation of GR through upstream MAP2K2/4, while another JNK inhibits GR transcriptional activity by enhancing the nuclear export of the receptor[1][2].

Ser/Thr Kinase Related Products (42):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-151574
    PfGSK3/PfPK6-IN-1
    		Inducer 99.38%
    PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research.
    PfGSK3/PfPK6-IN-1
  • HY-P3935
    Arg-Gly-Tyr-Ser-Leu-Gly
    		99.44%
    Arg-Gly-Tyr-Ser-Leu-Gly is corresponding to the sequence of residues from 21 through 26 in lysozyme. Arg-Gly-Tyr-Ser-Leu-Gly can be used as a substrate for the protein kinase, and phosphorylated at serine residue by protein kinase.
    Arg-Gly-Tyr-Ser-Leu-Gly
  • HY-E70839
    KHS1 Recombinant Human Active Protein Kinase
    MAP4K5 (KHS1) belongs to the mammalian Ste20-like serine/threonine kinase family. MAP4K5 plays an important role in regulating a range of cellular responses and is involved in Wnt signaling in hematopoietic cells. KHS1 Recombinant Human Active Protein Kinase is a recombinant KHS1 protein that can be used to study KHS1-related functions.
    KHS1 Recombinant Human Active Protein Kinase
  • HY-178974
    STK10-IN-1
    		Inhibitor
    SLK/STK10-IN-2 (Compound 23) is a highly selective STK10 inhibitor, with a Kd of 365 nM and an IC50 of 0.85 μM. SLK/STK10-IN-2 exhibits EC50 of 0.89 μM in NanoBRET cell experiments. SLK/STK10-IN-2 shows no significant binding to SLK, STK3/4. SLK/STK10-IN-2 can be used to study STK10-related diseases (such as abnormal lymphocyte migration).
    STK10-IN-1
  • HY-E70729
    ICK Recombinant Human Active Protein Kinase
    The intestinal cell kinase (ICK) protein belongs to the ros-cross hybridizing kinase (RCK) family. ICK is a ciliary protein, involved in ciliogenesis and regulation of intraflagellar transport (IFT). ICK Recombinant Human Active Protein Kinase is a recombinant ICK protein that can be used to study ICK-related functions.
    ICK Recombinant Human Active Protein Kinase
  • HY-10424A
    Milciclib maleate
    		Inhibitor
    Milciclib (PHA-848125) maleate is a cyclin-dependent kinase inhibitor that impairs melanoma cell growth and modulates gene expression involved in cell cycle regulation. Milciclib maleate has been shown to significantly affect the expression of various genes, including down-regulating PTTG1, contributing to its antiproliferative activity. Milciclib maleate enhances sensitivity to treatment in p53 mutated melanoma cells when combined with PTTG1 silencing.
    Milciclib maleate
  • HY-178214
    CSBP ligand 1
    		Ligand
    CSBP ligand 1 (Compound 36) is a ligand of CSBP, with an IC50 of 0.08 μM for CSBP binding. CSBP ligand 1 can inhibit the production of TNF in mice treated with LPS (HY-D1056). CSBP ligand 1 has no significant inhibitory activity against PGHS-1 (IC50: 16 μM) and 5-LO (IC50: 60 μM). CSBP ligand 1 can be used in the research of inflammation-related diseases.
    CSBP ligand 1
  • HY-177912
    ILK-IN-4
    		Inhibitor
    ILK-IN-4 (compound 49) is an integrin-linked kinase (ILK) inhibitor. ILK-IN-4 can be used for cancer research.
    ILK-IN-4
  • HY-E70788
    BARK1 Recombinant Human Active Protein Kinase
    BARK1 Recombinant Human Active Protein Kinase is a membrane LRR-RLK (leucine-rich repeat receptor-like kinase) protein that specifically binds to BAK1 and its homologs.
    BARK1 Recombinant Human Active Protein Kinase
  • HY-128491
    UNC10112785
    		Inhibitor
    UNC10112785 is a serine/threonine kinase inhibitor with a human GSK-3β IC50 of 0.031 μM, human CDK-2 IC50 of 0.016 μM, and human CDK-4 IC50 of 1.99 μM. UNC10112785 can be used for the research of type 2 diabetes.
    UNC10112785
  • HY-171294
    Protein kinase inhibitor 16
    		Inhibitor
    Protein kinase inhibitor 16 exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
    Protein kinase inhibitor 16
  • HY-116611
    IMB-YH-8
    		Inhibitor
    IMB-YH-8 is a serine/threonine protein kinase (PknB) inhibitor. IMB-YH-8 has strong antibacterial activity against Mycobacterium tuberculosis (MIC = 0.25 µg/mL). IMB-YH-8 can be used in the research of tuberculosis.
    IMB-YH-8
  • HY-171276
    Anti-neuroinflammation agent 3
    		Inhibitor
    Anti-neuroinflammation agent 3 (Compound A.10.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
    Anti-neuroinflammation agent 3
  • HY-101270R
    STK16-IN-1 (Standard)
    		Inhibitor
    STK16-IN-1 (Standard) is the analytical standard of STK16-IN-1 (HY-101270). This product is intended for research and analytical applications. STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
    STK16-IN-1 (Standard)
  • HY-171291
    Protein kinase inhibitor 14
    		Inhibitor
    Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects against a variety of serine/threonine kinase and receptor/non-receptor tyrosine kinase.
    Protein kinase inhibitor 14
  • HY-169587
    Protein kinase G inhibitor-3
    		Inhibitor
    Protein kinase G inhibitor-3 (Compound 177) is an inhibitor of mycobacterial serine/threonine protein kinases. Protein kinase G inhibitor-3 can be used in the research of diseases related to mycobacterial infections.
    Protein kinase G inhibitor-3
  • HY-171293
    Protein kinase inhibitor 15
    		Inhibitor
    Protein kinase inhibitor 15 (Compound A.35.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase.
    Protein kinase inhibitor 15
  • HY-103020R
    BAY-1816032 (Standard)
    		Inhibitor
    BAY-1816032 (Standard) is the analytical standard of BAY-1816032 (HY-103020). This product is intended for research and analytical applications. BAY-1816032, a chemical probe, is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM.
    BAY-1816032 (Standard)
  • HY-122735
    Inh2-B1
    		Inhibitor
    Inh2-B1 is a Ser/Thr protein kinase (STK1) inhibitor. Inh2-B1 specifically inhibits STK1 activity by directly binding to its ATP-binding catalytic domain. Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) clearly.
    Inh2-B1
  • HY-104001R
    BAY-524 (Standard)
    		Inhibitor
    BAY-524 (Standard) is the analytical standard of BAY-524 (HY-104001). This product is intended for research and analytical applications. BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents.
    BAY-524 (Standard)