Ser/Thr Kinase Degrader
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PROTAC TSSK1 Degrader-1
0 ImagesCat. No.: HY-184428PROTAC TSSK1 Degrader-1 is a TSSK1 PROTAC degrader with a DC50 of 10.8 nM and an IC50 of 56.8 nM. PROTAC TSSK1 Degrader-1 reduces sperm motility and impairs in vitro fertilization capacity. PROTAC TSSK1 Degrader-1 undergoes metabolic N-dealkylation and exhibits high efflux properties. PROTAC TSSK1 Degrader-1 is applicable to studies related to male fertility.
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PROTAC TRIB2 degrader-1
0 ImagesCat. No.: HY-168274CAS No.: 3100306-42-8PROTAC TRIB2 degrader-1 is a selective TRIB2 PROTAC degrader with a DC50 of 16.84 nM in PC3 cells. PROTAC TRIB2 degrader-1 directly interacts with TRIB2 and induces its degradation via the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 inhibits cancer cell proliferation and promotes apoptosis by inducing PARP cleavage. PROTAC TRIB2 degrader-1 is applicable to relevant research on prostate cancer.
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PROTAC TSSK1 Degrader-2
0 ImagesCat. No.: HY-184464PROTAC TSSK1 Degrader-2 is a cereblon-recruiting PROTAC degrader targeting TSSK1, with a DC50 of 10.8 nM and an IC50 of 56.8 nM against TSSK1. PROTAC TSSK1 Degrader-2 recruits the cereblon E3 ubiquitin ligase to induce proteasomal degradation of TSSK1. PROTAC TSSK1 Degrader-2 reduces the motility and in vitro fertilization capacity of mouse sperm. PROTAC TSSK1 Degrader-2 undergoes metabolic N-dealkylation and exhibits high efflux. PROTAC TSSK1 Degrader-2 can be used in studies related to male fertility.
