2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Kinase
  5. Ser/Thr Kinase Degrader

Ser/Thr Kinase Degrader

Ser/Thr Kinase Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-171658
    R1-ICR-5
    		Degrader 98.73%
    R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation.