Milciclib maleate
Based on 7 publication(s) in Google Scholar
Milciclib (PHA-848125) maleate is a cyclin-dependent kinase inhibitor that impairs melanoma cell growth and modulates gene expression involved in cell cycle regulation. Milciclib maleate has been shown to significantly affect the expression of various genes, including down-regulating PTTG1, contributing to its antiproliferative activity. Milciclib maleate enhances sensitivity to treatment in p53 mutated melanoma cells when combined with PTTG1 silencing.
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- CAS No.: 1253645-38-3
- Formula: C29H36N8O5
- Molecular Weight:576.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Milciclib maleate
More- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- J Exp Med. 2022 Jan 3;219(1):e20210789. [Abstract]
- Sci Rep. 2021 Mar 8;11(1):5374. [Abstract]
- Sci Rep. 2020 Jul 17;10(1):11921. [Abstract]
- Arch Pharm (Weinheim). 2024 Sep;357(9):e2400066. [Abstract]
- University of Washington. 2025.
- Technical University of Munich. 24.01.2018.
Biological Activity
Chemical Information
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CAS No. 1253645-38-3
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Molecular Weight 576.65
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Formula C29H36N8O5
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SMILES
O=C(NC)C1=NN(C2=C1C(C)(CC3=CN=C(N=C23)NC4=CC=C(C=C4)N5CCN(CC5)C)C)C.OC(/C=C\C(O)=O)=O
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Synonyms
PHA-848125 maleate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
J Exp Med
2022 Jan 3;219(1):e20210789. PMID: 34825915 -
Sci Rep
2021 Mar 8;11(1):5374. PMID: 33686114 -
Sci Rep
Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer. [Abstract]2020 Jul 17;10(1):11921. PMID: 32681070 -
Arch Pharm (Weinheim)
Discovery of potent CSK inhibitors through integrated virtual screening and molecular dynamic simulation. [Abstract]2024 Sep;357(9):e2400066. PMID: 38809025 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Milciclib maleate Related Classifications
HY-10424A Related Classifications
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