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Trofinetide  (Synonyms: NNZ-2566)

製品番号: HY-16757 純度: 99.94%
COA 取扱説明書

Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.

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Trofinetide 構造式

Trofinetide 構造式

CAS 番号 : 853400-76-7

容量 価格(税別) 在庫状況 数量
Solution
10 mM * 1 mL in Water USD 275 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 275 在庫あり
Estimated Time of Arrival: December 31
Solid
1 mg USD 132 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 396 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 600 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 1800 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 2520 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.

体内実験

Trofinetide (NNZ-2566) suppresses penetrating ballistic-like brain injury (PBBI) induced inflammatory cell infiltration at 3 days following PBBI as compare to vehicle treatment. Trofinetide treatment significantly reduces the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%) and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. Trofinetide treatment does not affect the PBBI-induced up-regulation of IL-6 expression at any time point, but does produce significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI[1]. The high doses of Trofinetide (NNZ-2566) (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring beyond 2 h after permanent middle cerebral artery occlusion (pMCAo). All doses of Trofinetide completely suppress the delayed occurrence of NCS as compare with the vehicle-treated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験
分子量

315.32

分子式

C13H21N3O6

CAS 番号
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Protect from light, stored under nitrogen
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 110 mg/mL (348.85 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (158.57 mM)

DMSO : 25 mg/mL (79.28 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1714 mL 15.8569 mL 31.7138 mL
5 mM 0.6343 mL 3.1714 mL 6.3428 mL
10 mM 0.3171 mL 1.5857 mL 3.1714 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (317.14 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
純度とドキュメンテーション

純度: 99.94%

参考文献
動物実験
[1]

Three groups of eight rats are evaluated: vehicle/sham, vehicle/penetrating ballistic-like brain injury (PBBI), Trofinetide (NNZ-2566)/PBBI. A bolus injection of 10 mg/kg Trofinetide or 1 mL/kg saline (vehicle) is administered intravenously (IV) to each animal at 30 minutes post-PBBI surgery, immediately followed by a continuous IV infusion of Trofinetide at a rate of 3 mg/kg/h or an equal volume of vehicle for various durations (1 h, 4 h, or 12 h). Rats are subsequently euthanized and brain tissues are collected for processing at 1 h, 4 h, 12 h, 24 h, 3, and 7 days following the initiation of treatment[1].

MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

参考文献
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製品名:
Trofinetide
製品番号:
HY-16757
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