Tyr-Gly-Gly-Phe-Met-OH (Synonyms: Met-Enkephalin; Methionine enkephalin; Metenkefalin)

Name: Tyr-Gly-Gly-Phe-Met-OH
Brand: MedChemExpress
SKU: HY-P0073
Rating: 5.0 (4 reviews)

Cat. No.: HY-P0073 Pureza: 99.56%: Ficha de datos
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Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

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Síntesis de péptidos personalizados

Tyr-Gly-Gly-Phe-Met-OH Estructura química

No. CAS : 58569-55-4

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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Revisión del cliente

Based on 4 publication(s) in Google Scholar

4 Publications Citing Use of MCE Tyr-Gly-Gly-Phe-Met-OH

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Opioid Receptor:

Ver todas las isoformas

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Revisión del cliente

Descripciòn

Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

IC₅₀ & Target

Opioid Receptor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	1.03 1 Compound: [Met5]-enkephalin	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	[PMID: 22197670]
HEK293	EC₅₀	1.03 1 Compound: Met-enk	Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay	[PMID: 19362480]
HEK293	EC₅₀	1.03 1 Compound: [Met5]-enkephalin	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	[PMID: 22197670]
HEK293	EC₅₀	1.03 1 Compound: Met-enk	Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay	[PMID: 19362480]
HEK293	IC₅₀	13 1 Compound: Met-Enk	Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay	[PMID: 26465170]
HEK293	IC₅₀	6.4 1 Compound: Met-Enk	Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay	[PMID: 26465170]
HEK293	IC₅₀	6.4 1 Compound: Met-Enk	Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay	[PMID: 26465170]
HEK293	IC₅₀	13 1 Compound: Met-Enk	Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay	[PMID: 26465170]
HEK293	EC₅₀	1.03 1 Compound: Met-enk	Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay	[PMID: 19362480]
HEK293	EC₅₀	1.03 1 Compound: [Met5]-enkephalin	Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay Agonist activity at human recombinant delta opioid receptor expressed in human HEK293 cells by [35S]GTPgammaS binding assay	[PMID: 22197670]
HEK293	IC₅₀	13 1 Compound: Met-Enk	Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay Agonist activity at mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay	[PMID: 26465170]
HEK293	IC₅₀	6.4 1 Compound: Met-Enk	Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay Agonist activity at delta receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by bioluminescent assay	[PMID: 26465170]

In Vitro

Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

Peso molecular

573.66

Fòrmula

C₂₇H₃₅N₅O₇S

No. CAS

58569-55-4

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Gly-Gly-Phe-Met

Sequence Shortening

YGGFM

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : ≥ 40 mg/mL (69.73 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 5 mg/mL (8.72 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7432 mL	8.7160 mL	17.4319 mL
5 mM	0.3486 mL	1.7432 mL	3.4864 mL
10 mM	0.1743 mL	0.8716 mL	1.7432 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.56%

Select Batch:

Ficha de datos (271 KB) SDS (393 KB)

COA (245 KB) LCMS (87 KB) Elemental Analysis Report (105 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.7432 mL	8.7160 mL	17.4319 mL	43.5798 mL
H₂O / DMSO	5 mM	0.3486 mL	1.7432 mL	3.4864 mL	8.7160 mL
DMSO	10 mM	0.1743 mL	0.8716 mL	1.7432 mL	4.3580 mL
	15 mM	0.1162 mL	0.5811 mL	1.1621 mL	2.9053 mL
	20 mM	0.0872 mL	0.4358 mL	0.8716 mL	2.1790 mL
	25 mM	0.0697 mL	0.3486 mL	0.6973 mL	1.7432 mL
	30 mM	0.0581 mL	0.2905 mL	0.5811 mL	1.4527 mL
	40 mM	0.0436 mL	0.2179 mL	0.4358 mL	1.0895 mL
	50 mM	0.0349 mL	0.1743 mL	0.3486 mL	0.8716 mL
	60 mM	0.0291 mL	0.1453 mL	0.2905 mL	0.7263 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Tyr-Gly-Gly-Phe-Met-OH Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyr-Gly-Gly-Phe-Met-OH58569-55-4Met-Enkephalin Methionine enkephalin MetenkefalinOpioid ReceptorInhibitorinhibitorinhibit

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Tyr-Gly-Gly-Phe-Met-OH (Synonyms: Met-Enkephalin; Methionine enkephalin; Metenkefalin)

Revisión del cliente

Tyr-Gly-Gly-Phe-Met-OH Related Antibodies

4 Publications Citing Use of MCE Tyr-Gly-Gly-Phe-Met-OH

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Opioid Receptor:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Tyr-Gly-Gly-Phe-Met-OH Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Tyr-Gly-Gly-Phe-Met-OH Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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