1. Neuronal Signaling
    Stem Cell/Wnt
  2. Notch
  3. Z-Ile-Leu-aldehyde

Z-Ile-Leu-aldehyde (Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

Cat. No.: HY-12465 Purity: 98.10%
Handling Instructions

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.

For research use only. We do not sell to patients.

Z-Ile-Leu-aldehyde Chemical Structure

Z-Ile-Leu-aldehyde Chemical Structure

CAS No. : 161710-10-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].

In Vitro

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2].


Cell Line: CD4+ T cells from C57BL/6 mice.
Concentration: 25 μM.
Incubation Time: 24, 48, 72 hours.
Result: DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line: MOPC315.BM cells.
Concentration: 0, 12, 15 μM.
Incubation Time: 24-48 h hours.
Result: Reduced viability and induced apoptosis in MOPC315.BM cells
In Vivo

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].

Animal Model: MOPC315.BM mouse model[2].
Dosage: 10 mg/kg.
Administration: Intraperitoneally either for 14 days.
Result: Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice.
Molecular Weight







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Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 41 mg/mL (113.12 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7589 mL 13.7946 mL 27.5893 mL
5 mM 0.5518 mL 2.7589 mL 5.5179 mL
10 mM 0.2759 mL 1.3795 mL 2.7589 mL
*Please refer to the solubility information to select the appropriate solvent.
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Z-Ile-Leu-aldehydeZ-IL-CHOGSI-XIIγ-Secretase inhibitor XIINotchγ-secretaseApoptosisGamma secretaseCD4IL-17Th17RORγtInhibitorinhibitorinhibit

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