Cat. No.: HY-12465

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Z-Ile-Leu-aldehyde

(Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.

For research use only. We do not sell to patients.

Purity: 97.0%
CAS No.: 161710-10-7
Formula: C₂₀H₃₀N₂O₄
Molecular Weight:362.46

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Z-Ile-Leu-aldehyde Chemical Structure

CAS No.: 161710-10-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch^[1]^[2].

In Vitro

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays^[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCRsup>[1]

Cell Line:

CD4⁺ T cells from C57BL/6 mice.
Concentration:

25 μM.
Incubation Time:

24, 48, 72 hours.
Result:

DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line:

MOPC315.BM cells.
Concentration:

0, 12, 15 μM.
Incubation Time:

24-48 h hours.
Result:

Reduced viability and induced apoptosis in MOPC315.BM cells

In Vivo

Z-Ile-Leu-aldehyde (GSI XII, 10?mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MOPC315.BM mouse model^[2].
Dosage:

10 mg/kg.
Administration:

Intraperitoneally either for 14 days.
Result:

Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice.

Chemical Information

CAS No. 161710-10-7
Appearance Solid
Molecular Weight 362.46
Formula C₂₀H₃₀N₂O₄
Color White to off-white
SMILES

O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CC(C)C)=O)[C@@H](C)CC
Synonyms

Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Biochem Pharmacol

Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance. [Abstract]

2024 Feb:220:115991. PMID: 38135129
Front Mol Biosci

Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway. [Abstract]

2021 Oct 22;8:652443. PMID: 34746227

Solvent & Solubility

In Vitro:

DMSO : ≥ 41 mg/mL (113.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7589 mL

13.7946 mL

27.5893 mL

5 mM

0.5518 mL

2.7589 mL

5.5179 mL

10 mM

0.2759 mL

1.3795 mL

2.7589 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Reem Suleiman, et al. The Role Of Notch In Th17 Differentiation. University of Massachusetts Amherst. 9-2013.

[2]. Schwarzer R, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014 Jun 13;4:e217. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7589 mL	13.7946 mL	27.5893 mL	68.9731 mL
	5 mM	0.5518 mL	2.7589 mL	5.5179 mL	13.7946 mL
	10 mM	0.2759 mL	1.3795 mL	2.7589 mL	6.8973 mL
	15 mM	0.1839 mL	0.9196 mL	1.8393 mL	4.5982 mL
	20 mM	0.1379 mL	0.6897 mL	1.3795 mL	3.4487 mL
	25 mM	0.1104 mL	0.5518 mL	1.1036 mL	2.7589 mL
	30 mM	0.0920 mL	0.4598 mL	0.9196 mL	2.2991 mL
	40 mM	0.0690 mL	0.3449 mL	0.6897 mL	1.7243 mL
	50 mM	0.0552 mL	0.2759 mL	0.5518 mL	1.3795 mL
	60 mM	0.0460 mL	0.2299 mL	0.4598 mL	1.1496 mL
	80 mM	0.0345 mL	0.1724 mL	0.3449 mL	0.8622 mL
	100 mM	0.0276 mL	0.1379 mL	0.2759 mL	0.6897 mL

Keywords

Z-Ile-Leu-aldehyde

2 Cited Publications

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Z-Ile-Leu-aldehyde

Apoptosis Compound Library

Neuronal Signaling Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Covalent Screening Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Cancer Stem Cells Compound Library

Membrane Protein-targeted Compound Library

Cysteine Targeted Covalent Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Publications Citing Use of MedChemExpress (MCE) Z-Ile-Leu-aldehyde

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Z-Ile-Leu-aldehyde Related Classifications

HY-12465 Related Classifications