1. Neuronal Signaling
    Stem Cell/Wnt
    Apoptosis
  2. Notch
    γ-secretase
    Apoptosis
  3. Z-Ile-Leu-aldehyde

Z-Ile-Leu-aldehyde (Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

Cat. No.: HY-12465 Purity: 98.10%
Handling Instructions

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.

For research use only. We do not sell to patients.

Z-Ile-Leu-aldehyde Chemical Structure

Z-Ile-Leu-aldehyde Chemical Structure

CAS No. : 161710-10-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].

In Vitro

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2].

RT-PCRsup>[1]

Cell Line: CD4+ T cells from C57BL/6 mice.
Concentration: 25 μM.
Incubation Time: 24, 48, 72 hours.
Result: DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line: MOPC315.BM cells.
Concentration: 0, 12, 15 μM.
Incubation Time: 24-48 h hours.
Result: Reduced viability and induced apoptosis in MOPC315.BM cells
In Vivo

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].

Animal Model: MOPC315.BM mouse model[2].
Dosage: 10 mg/kg.
Administration: Intraperitoneally either for 14 days.
Result: Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice.
Molecular Weight

362.46

Formula

C₂₀H₃₀N₂O₄

CAS No.

161710-10-7

SMILES

O=C(OCC1=CC=CC=C1)N[[email protected]](C(N[[email protected]](C=O)CC(C)C)=O)[[email protected]@H](C)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 41 mg/mL (113.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7589 mL 13.7946 mL 27.5893 mL
5 mM 0.5518 mL 2.7589 mL 5.5179 mL
10 mM 0.2759 mL 1.3795 mL 2.7589 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Z-Ile-Leu-aldehydeZ-IL-CHOGSI-XIIγ-Secretase inhibitor XIINotchγ-secretaseApoptosisGamma secretaseCD4IL-17Th17RORγtInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Z-Ile-Leu-aldehyde
Cat. No.:
HY-12465
Quantity:
MCE Japan Authorized Agent: