2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. AACOCF3

AACOCF3  (Synonyms: Arachidonyl trifluoromethyl ketone)

製品番号: HY-108611 純度: 99.89%
COA 取扱説明書 Technical Support

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease.

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CAS 番号 : 149301-79-1

容量 価格（税別） 在庫状況 数量
Solvent
5 mg (28.05 mM * 500 μL in Ethanol) USD 150 在庫あり
Solvent
10 mg (28.05 mM * 1 mL in Ethanol) USD 270 在庫あり

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カスタマーレビュー

Based on 4 publication(s) in Google Scholar

AACOCF3 関連抗体

Top Publications Citing Use of Products

    AACOCF3 purchased from MedChemExpress. Usage Cited in: J Enzyme Inhib Med Chem. 2025 Dec;40(1):2547259.  [Abstract]

    AACOCF3 (2 μM) significantly decreased the protein expression levels of 12/15-LOX, cPLA2, p-p38 MAPK/p38 MAPK, and TNF-α in OE-treated HT22 cells.

    AACOCF3 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Feb:200:107082.  [Abstract]

    IC50 of AACOCF3 (1-100 μM) in MHCC97H and PLC/PRF/5.

    AACOCF3 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul:129:155648.

    AACOCF3 (20 μM) significantly decreased the activity and content of cPLA2, AA, IL-1β, and TNF-α in NRK52E cells compared to those in the BRB group.

    AACOCF3 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul:129:155648.

    AACOCF3 (20 μM) attenuated the BRB-induced increases in the P-cPLA2/cPLA2 ratio and the levels of caspase-1 and caspase-3 in NRK52E cells.

    AACOCF3 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Mar:116:109637.  [Abstract]

    AACOCF3 (1 μM; 4 h) decreased cPLA2 activity in LPS-treated MHS cells.

    Phospholipase アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Phospholipase A PLD Phospholipase C

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    • 純度とドキュメンテーション

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    • カスタマーレビュー

    製品説明

    AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease[1][2][3].

    Cellular Effect
    Cell Line Type Value Description References
    HL-60 IC50
    29 3
    Compound: 1
    Inhibition of [3H]arachidonic acid production by stimulated HL60 cells.
    Inhibition of [3H]arachidonic acid production by stimulated HL60 cells.
    		[PMID: 11882004]
    HL-60 IC50
    29 3
    Compound: 1
    Inhibition of [3H]arachidonic acid production by stimulated HL60 cells.
    Inhibition of [3H]arachidonic acid production by stimulated HL60 cells.
    		[PMID: 11882004]
    HL-60 IC50
    29 3
    Compound: 1
    Inhibition of [3H]arachidonic acid production by stimulated HL60 cells.
    Inhibition of [3H]arachidonic acid production by stimulated HL60 cells.
    		[PMID: 11882004]
    THP-1 IC50
    41000 1
    Compound: AACOCF3
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    THP-1 IC50
    86 3
    Compound: AACOCF3
    Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    THP-1 IC50
    86000 1
    Compound: AACOCF3
    Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    THP-1 IC50
    41 3
    Compound: AACOCF3
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187
    		[PMID: 11229777]
    体外実験

    AACOCF3 inhibits the release of arachidonic acid from calcium ionophore-challenged U937 cells (IC50= 8 μM, 2 x 106 cells ml-1) and from platelets (IC50= 2 μM, 4 x 107 cells ml-1)[1].
    AACOCF3 (10 μM) suppresses phosphate-induced calcification and osteogenic/chondrogenic signaling in HAoSMCs. AACOCF3 significantly inhibits both basal and Pi-induced release of arachidonic acid, the product of PLA2 activity[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    AACOCF3 関連抗体
    体内実験

    AACOCF3 (10 mg/kg; gavage; 5 days a week; ApoE–/– mice (6-week-old males) were fed a high-cholesterol diet) significantly reduces type III collagen plaque expression but had no significant influence on total collagen accumulation[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    356.47

    分子式

    C21H31F3O
    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(C(F)(F)F)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Solution, -20°C, 2 years
    純度とドキュメンテーション

    純度: 99.89%

    COA (237 KB) HNMR (256 KB) LCMS (92 KB)

    取扱説明書 (2659 KB)
    参考文献
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    AACOCF3 Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AACOCF3149301-79-1Arachidonyl trifluoromethyl ketoneAACOCF 3AACOCF-3Phospholipasevascularcalcificationglucose-inducedinsulinsecretionselectiveInhibitorinhibitorinhibit

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    製品名:
    AACOCF3
    製品番号:
    HY-108611
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