2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine 5'-monophosphate disodium

Adenosine 5'-monophosphate disodium  (Synonyms: アデノシン 5'-一りん酸二ナトリウム)

製品番号: HY-W011012 純度: 99.92%
COA 取扱説明書 Technical Support

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.

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CAS 番号 : 4578-31-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in Water USD 33 在庫あり
Solid
100 mg $30 在庫あり
500 mg $50 在庫あり
1 g $70 在庫あり
5 g $113 在庫あり
10 g $160 在庫あり
25 g $240 在庫あり
50 g   お問い合わせ  

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カスタマーレビュー

Based on 18 publication(s) in Google Scholar

Other Forms of Adenosine 5'-monophosphate disodium:

Adenosine 5'-monophosphate disodium 関連抗体

Top Publications Citing Use of Products

    Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2025 Jun 2;16(1):277.  [Abstract]

    Flow cytometry analysis of adenosine A2aR and A2bR expression treated with Adenosine monophosphate (AMP) (100 μM).

    Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 May 14:708:149814.

    The levels of ROS was significantly improved in the AMPD2 overexpression group after treatment with Adenosine monophosphate (AMP) (10 μM, 24 h).

    Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2024 May 14:708:149814.

    Lower expression of total p38, phosphorylated p38 and Gpx4 could be observed after Adenosine monophosphate (AMP) (10 μM, 24 h) treatment in the AMPD2 overexpression group detected by western blot analysis.

    Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2023 Sep 29;14(1):277.  [Abstract]

    IFN-γ production was detected by ELISA in the cell culture supernatant, ERCs or NC-ERCs significantly inhibited the differentiation of activated CD4+ T cells to Th1 cells compared with CD73-KO-ERCs, as well as the production of IFN-γ, especially in the presence of Adenosine monophosphate (AMP) (50 μM, 72 h).

    Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2023 Sep 29;14(1):277.  [Abstract]

    Adenosine monophosphate (AMP) (50 μM, 72 h) was introduced to the culture medium to ensure sufficient substrate for CD73 in all situations, the reduction of CD69 expression on CD4+ T cells was more apparent when cultured with NC-ERCs than CD73-KO-ERCs.

    Adenosine 5'-monophosphate disodium purchased from MedChemExpress. Usage Cited in: Genes (Basel). 2022 Dec 16;13(12):2384.  [Abstract]

    The Survival rate of M. coruscus larvae after being treated with Adenosine monophosphate (AMP) (0.5, 1. 2.5 mM, 72 h) The figures in the legend represent the concentration (mM).

    Adenosine Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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    • 純度とドキュメンテーション

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    製品説明

    Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].

    IC50 & Target[3]

    A2BR

     

    体内実験

    Adenosine 5'-monophosphate (10 and 13 mg/L in distilled water, for 25 weeks) disodium improves glucose metabolism in mice with HFD-induced diabetes[1].
    Adenosine 5'-monophosphate (40-800 mg/kg, i.p.) lowers body temperature via the adenosine receptor in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 J mice with high-fat diet-induced diabetes[1]
    Dosage: 10 and 13 mg/L
    Administration: Added in distilled water, for 25 weeks
    Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.
    分子量

    391.18

    分子式

    C10H12N5Na2O7P
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (255.64 mM; Need ultrasonic)

    DMSO : 2 mg/mL (5.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5564 mL 12.7818 mL 25.5637 mL
    5 mM 0.5113 mL 2.5564 mL 5.1127 mL
    10 mM 0.2556 mL 1.2782 mL 2.5564 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.92%

    COA (254 KB) HNMR (112 KB) RP-HPLC (101 KB) LCMS (233 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.5564 mL 12.7818 mL 25.5637 mL 63.9092 mL
    5 mM 0.5113 mL 2.5564 mL 5.1127 mL 12.7818 mL
    H2O 10 mM 0.2556 mL 1.2782 mL 2.5564 mL 6.3909 mL
    15 mM 0.1704 mL 0.8521 mL 1.7042 mL 4.2606 mL
    20 mM 0.1278 mL 0.6391 mL 1.2782 mL 3.1955 mL
    25 mM 0.1023 mL 0.5113 mL 1.0225 mL 2.5564 mL
    30 mM 0.0852 mL 0.4261 mL 0.8521 mL 2.1303 mL
    40 mM 0.0639 mL 0.3195 mL 0.6391 mL 1.5977 mL
    50 mM 0.0511 mL 0.2556 mL 0.5113 mL 1.2782 mL
    60 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
    80 mM 0.0320 mL 0.1598 mL 0.3195 mL 0.7989 mL
    100 mM 0.0256 mL 0.1278 mL 0.2556 mL 0.6391 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Adenosine 5'-monophosphate disodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Adenosine 5'-monophosphate disodium4578-31-8Adenosine ReceptorP1 receptorHFDdiabetesAMPKnucleotideATP metabolismInhibitorinhibitorinhibit

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    製品名:
    Adenosine 5'-monophosphate disodium
    製品番号:
    HY-W011012
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