Aminoxyacetic acid (Synonyms: Carboxymethoxylamine; Aminooxyacetate)

Name: Aminoxyacetic acid
Brand: MedChemExpress
SKU: HY-107994A
Rating: 5.0 (24 reviews)

Cat. No.: HY-107994A Purity: 95.0%: Data Sheet
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Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.

For research use only. We do not sell to patients.

CAS No. : 645-88-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 24 publication(s) in Google Scholar

Other Forms of Aminoxyacetic acid:

Aminooxyacetic acid hemihydrochloride In-stock

24 Publications Citing Use of MCE Aminoxyacetic acid

Cell Migration/Invasion Assay

In Vivo Efficacy Study

Cell Proliferation/Viability Assay

: Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]; Aminooxyacetic acid hemihydrochloride (AOA) (20 μM; 48 h) decreased the migration and invasion of HCC cells expressing p5372P variant.

: Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]; A Parental or PSAT1 knockout PLC/PRF/5 cells were tail intravenously injected into BALB/c nude mice and the mice were treated with vehicle or Aminooxyacetic acid hemihydrochloride (AOA) (10 mg/kg; i.p.; once daily for 14 d). Aminooxyacetic acid hemihydrochloride (AOA) treatment significantly inhibited the lung metastasis of cancer cells expressing the p5372P variant in vivo.

: Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]; The interaction between PSAT1 and p53 was diminished by Aminooxyacetic acid hemihydrochloride (AOA) (10-20 μM) treatment while the protein level of PSAT1 was not significantly changed.

: Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65. [Abstract]; Cell viability of Hep3B cells transfected with vector, p53-72P, and p53-72R plasmids was assessed. Cells were treated with regorafenib alone or Aminooxyacetic acid hemihydrochloride (AOA) (10 μM) plus regorafenib at indicated concentrations. Aminooxyacetic acid hemihydrochloride (AOA) sensitized tumor cells containing vector and p53-72P to regorafenib, while exhibiting no obvious synergistic function with regorafenib in cells containing p53-72R.

: Aminoxyacetic acid purchased from MedChemExpress. Usage Cited in: Nat Metab. 2022 Feb;4(2):239-253. [Abstract]; Aminooxyacetic acid hemihydrochloride (GOT1) (1 mM; 2 d). Cell proliferation of H460 cells was quantified after treatment with inhibitors against the indicated enzymes.

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Description

Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.

IC₅₀ & Target

MAS^[1], GABA-T^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	140 μM Compound: AOAA	Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay Antiproliferative activity against human HT-29 cells assessed as decrease in cell viability after 24 hrs by CCK8 assay	[PMID: 30108705]
HT-29	IC₅₀	159.2 μM Compound: AOAA	Antiproliferative activity against human HT-29 cells after 24 hrs by CCK8 assay Antiproliferative activity against human HT-29 cells after 24 hrs by CCK8 assay	[PMID: 30108905]
HT-29	IC₅₀	286.7 μM Compound: AOAA	Antiproliferative activity against human HT-29 cells harboring CBS SiRNA after 24 hrs by CCK8 assay Antiproliferative activity against human HT-29 cells harboring CBS SiRNA after 24 hrs by CCK8 assay	[PMID: 30108905]

In Vitro

Aminooxyacetic acid hemihydrochloride (AOAA) dose-dependently decreases the survival of C6 glioma cells. Aminooxyacetic acid hemihydrochloride treatment produces a significant increase in the percentage of the cells arrested in the stage of G0/G1, as well as a significant decrease in the percentage of the cells at S phase and G2/M phase. Aminooxyacetic acid hemihydrochloride treatment leads to an obvious decrease in the number of the cells in the phase of cell division. Aminooxyacetic acid hemihydrochloride significantly increases the percentage of the cells in both early-stage apoptosis and necrosis. Treatment of the cells with 1 mM or 5 mM Aminooxyacetic acid hemihydrochloride leads to decreased levels of aging of the cells^[1]. Glutamine-dependent cell lines show greater inhibition of cell growth by Aminooxyacetic acid hemihydrochloride (AOA) compare with cells that are less glutamine dependent^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The accumulation of GABA in cerebellum and whole brain is initially very rapid, being significantly increased already 5 min after the injection of Aminooxyacetic acid (AOAA). The rapid initial accumulation becomes gradually slower and maximal levels (400 to 600 % of the control levels) reached 2 to 6 h after Aminooxyacetic acid treatment. Still 24 h after Aminooxyacetic acid treatment, the GABA levels are elevated by about 250%. From 2 to 6 h after Aminooxyacetic acid treatment, the convulsions are completely blocked. 24 h after Aminooxyacetic acid treatment, the convulsions are almost identical to the controls^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

91.07

Formula

C₂H₅NO₃

CAS No.

645-88-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CON

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 95.0%

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Data Sheet (270 KB) SDS (251 KB)

COA (243 KB) HNMR (230 KB)

Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7. [Content Brief]

[2]. Pagliusi SR, et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5. [Content Brief]

[3]. Korangath P, et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21(14):3263-73. [Content Brief]

Aminoxyacetic acid Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminoxyacetic acid645-88-5Carboxymethoxylamine AminooxyacetateGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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Aminoxyacetic acid (Synonyms: Carboxymethoxylamine; Aminooxyacetate)

Customer Review

Other Forms of Aminoxyacetic acid:

Aminoxyacetic acid Related Antibodies

24 Publications Citing Use of MCE Aminoxyacetic acid

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Aminoxyacetic acid Related Antibodies

Aminoxyacetic acid Related Classifications

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