Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)

Cat. No.: HY-P990791 Purity: 95.09%: Data Sheet
COA

SDS

FAQs
Technical Support

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71⁺ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) 화학구조

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) Featured Recommendations:

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

CD71/TfR1

In Vitro

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (10 μg/mL, 18-72 h) reduces transferrin receptor 1 expression and inhibits transferrin uptake in Group 2 innate lymphoid cells (ILC2s)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (150 μg, i.p., daily for 2 days) depletes CD71⁺ erythroid splenocytes and enhances bacterial clearance in endotoxemia neonatal mice models^[1].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (0.5 or 1.0 mg/mouse, i.v., at day 21 after tumor cell inoculation) inhibits anti-virus responses in P14 CD8⁺ T cells transferred lymphocytic choriomeningitis virus (LCMV)-infected mice bearing lewis lung cancer tumor^[2].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (100 μg, i.p., before each intranasal challenge) reduces lung ILC2s accumulation in Group 2 innate lymphoid cells (ILC2s)-dependent airway inflammation mice^[3].
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) (100 μg, i.v., daily from day 0 to 3) prolongs graft survival in Cardiac allograft mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cardiac allograft mice models^[1]
Dosage:	100 μg
Administration:	Intravenously injection, at day 0 and 1
Result:	Prolonged graft survival. Increased the CTL response to donor-specific alloantigen. Suppressed the MLR to donor-specific alloantigen. Reduced B7-expressing cells. Inhibited activation of allo-reactive T cells and migration of T cells into the allograft site. Suppressed the IL-15 mRNA and increased the Th2 cytokine IL-4 mRNA expression.

Gene ID

22042 [NCBI]

Accession

Q62351

Application

in vivo depletion of CD71+ cells

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

분자량

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Purity: 95.09%

Select Batch:

Data Sheet (262 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (66 KB) SEC-HPLC (166 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Wynn JL, et al. Neonatal CD71+ Erythroid Cells Do Not Modify Murine Sepsis Mortality. J Immunol. 2015 Aug 1;195(3):1064-70. [Content Brief]

[2]. Zhao L, et al. Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nat Med. 2018 Oct;24(10):1536-1544. [Content Brief]

[3]. Hurrell BP, et al. Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function. Sci Transl Med. 2024 May 8;16(746):eadk4728. [Content Brief]

[4]. Bayer AL, et al. Differential effects of transferrin receptor blockade on the cellular mechanisms involved in graft rejection. Transpl Immunol. 1999 Sep;7(3):131-9. [Content Brief]

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) Related Classifications

몰농도 계산기
농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)Transferrin ReceptorTfRCD71TransferrinTransferrin receptorLung cancerLCMVILC2sGraftInhibitorinhibitorinhibit

최근 본 상품:

상품명

Requested Quantity *

고객명 *

호칭

메일주소 *

전화번호 *

Department

회사명 *

City

도

Country or Region *

비고

상품명

Lot #

고객명 *

메일주소 *

전화번호

Department *