Tfrc - transferrin receptor Gene

Also Known as TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22042

Summary

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]

Tfrc Products (2)

mRNA Protein Name
NM_001357298.1 NP_001344227.1 transferrin receptor protein 1
NM_011638.4 NP_035768.1 transferrin receptor protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16893896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
10192390 MGI
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
19252502 MGI
involved in positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
26642240 MGI
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
26642240 MGI
involved in positive regulation of bone resorption IDA
IDA: Inferred from direct assay
19252502 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
26880306 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: Inferred from expression pattern
26880306 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
26880306 MGI
Cellular Component GO Annotation Evidence References Source
part of HFE-transferrin receptor complex IDA
IDA: Inferred from direct assay
16893896 MGI
located in cell surface IDA
IDA: Inferred from direct assay
17716972 MGI
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
18434600 MGI
located in early endosome IDA
IDA: Inferred from direct assay
26432893 MGI
located in endosome IDA
IDA: Inferred from direct assay
11092755 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
20424607 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
19724054 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
20080761 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10444069 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10444069 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
26880306 MGI
located in recycling endosome IDA
IDA: Inferred from direct assay
23395379 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transferrin receptor protein 1

  • mammary tumor virus receptor 1

Recombinant Tfrc Proteins

Cat. No. Product Name Accession Purity
HY-P72455 TFRC Protein, Mouse (HEK293, His) Q62351 (C89-F763) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14431 TFRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-RS23180 Tfrc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16743 Tfrc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990051 Delpacibart 98.06% Unkown
HY-P992144 Zareprumig Inhibitor / Unkown
HY-P992387 INA01 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfrc NCBI NCBI:7037