HDAC11-IN-3
Based on 1 Customer Validation
HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 2989934-63-4
- Formula: C18H11F3N2O2
- Molecular Weight:344.29
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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NF-κB Signaling Compound Library
HY-L014
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Reprogramming Compound Library
HY-L039
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Oxygen Sensing Compound Library
HY-L045
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Ferroptosis Compound Library
HY-L051
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Liver Cancer Compound Library
HY-L101
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Osteogenesis Compound Library
HY-L131
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Brain Cancer Compound Library
HY-L188
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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High-Efficiency Gene Editing Compound Library
HY-L244
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Lactylation Compound Library
HY-L249
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Alkyne Compound Library
HY-L258
Biological Activity
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HDAC11 4.1 nM (IC50) |
Chemical Information
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CAS No. 2989934-63-4
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Appearance Solid
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Molecular Weight 344.29
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Formula C18H11F3N2O2
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Color Off-white to pink
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SMILES
O=C(C1=C2C=C(NC2=CC=C1)C#CC3=CC=CC(C(F)(F)F)=C3)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (290.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9045 mL | 14.5226 mL | 29.0453 mL | 72.6132 mL |
| 5 mM | 0.5809 mL | 2.9045 mL | 5.8091 mL | 14.5226 mL | |
| 10 mM | 0.2905 mL | 1.4523 mL | 2.9045 mL | 7.2613 mL | |
| 15 mM | 0.1936 mL | 0.9682 mL | 1.9364 mL | 4.8409 mL | |
| 20 mM | 0.1452 mL | 0.7261 mL | 1.4523 mL | 3.6307 mL | |
| 25 mM | 0.1162 mL | 0.5809 mL | 1.1618 mL | 2.9045 mL | |
| 30 mM | 0.0968 mL | 0.4841 mL | 0.9682 mL | 2.4204 mL | |
| 40 mM | 0.0726 mL | 0.3631 mL | 0.7261 mL | 1.8153 mL | |
| 50 mM | 0.0581 mL | 0.2905 mL | 0.5809 mL | 1.4523 mL | |
| 60 mM | 0.0484 mL | 0.2420 mL | 0.4841 mL | 1.2102 mL | |
| 80 mM | 0.0363 mL | 0.1815 mL | 0.3631 mL | 0.9077 mL | |
| 100 mM | 0.0290 mL | 0.1452 mL | 0.2905 mL | 0.7261 mL |
HDAC11-IN-3 Related Classifications
HY-173444 Related Classifications
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