2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Transferrin Receptor Apoptosis Ferroptosis
  4. HDAC11-IN-3

HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research.

For research use only. We do not sell to patients.

HDAC11-IN-3

HDAC11-IN-3 Chemical Structure

CAS No. : 2989934-63-4

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Based on 1 publication(s) in Google Scholar

HDAC11-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research[1].

IC50 & Target[1]

HDAC11

4.1 nM (IC50)

Molecular Weight

344.29

Formula

C18H11F3N2O2
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(C1=C2C=C(NC2=CC=C1)C#CC3=CC=CC(C(F)(F)F)=C3)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (290.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9045 mL 14.5226 mL 29.0453 mL
5 mM 0.5809 mL 2.9045 mL 5.8091 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9045 mL 14.5226 mL 29.0453 mL 72.6132 mL
5 mM 0.5809 mL 2.9045 mL 5.8091 mL 14.5226 mL
10 mM 0.2905 mL 1.4523 mL 2.9045 mL 7.2613 mL
15 mM 0.1936 mL 0.9682 mL 1.9364 mL 4.8409 mL
20 mM 0.1452 mL 0.7261 mL 1.4523 mL 3.6307 mL
25 mM 0.1162 mL 0.5809 mL 1.1618 mL 2.9045 mL
30 mM 0.0968 mL 0.4841 mL 0.9682 mL 2.4204 mL
40 mM 0.0726 mL 0.3631 mL 0.7261 mL 1.8153 mL
50 mM 0.0581 mL 0.2905 mL 0.5809 mL 1.4523 mL
60 mM 0.0484 mL 0.2420 mL 0.4841 mL 1.2102 mL
80 mM 0.0363 mL 0.1815 mL 0.3631 mL 0.9077 mL
100 mM 0.0290 mL 0.1452 mL 0.2905 mL 0.7261 mL
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HDAC11-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC11-IN-32989934-63-4HDACTransferrin ReceptorApoptosisFerroptosisHistone deacetylasesTfRCD71AMLU937 cellsHEK-293T cellsferroptosisC57BL/6 miceInhibitorinhibitorinhibit

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